Coanalgesics for chronic pain therapy: A narrative review

Matthew J. Bair, Tamara R. Sanderson

Research output: Contribution to journalArticle

11 Scopus citations


Chronic pain is inadequately treated in many patients, which has led clinicians and researchers to investigate new indications for existing medications with pain-relieving or adjuvant properties. These medications are known as coanalgesics. This review provides an evidence-based overview of select coanalgesics that are used in clinical practice for a variety of neuropathic and musculoskeletal pain disorders. The coanalgesics include antidepressants, anticonvulsants, topical agents, skeletal muscle relaxants, and antispasmodic agents. An update on emergent treatments and uses is also presented. The goals of this article are to highlight coanalgesic treatment options that are currently available for patients with chronic pain as well as provide guidelines for their use in clinical practice.

Original languageEnglish (US)
Pages (from-to)140-150
Number of pages11
JournalPostgraduate Medicine
Issue number6
StatePublished - Nov 1 2011


  • Adjuvant analgesics
  • Antidepressants
  • Chronic pain
  • Coanalgesics
  • Musculoskeletal pain
  • Neuropathic pain

ASJC Scopus subject areas

  • Medicine(all)

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