Coexpression of angiogenic factors in brain arteriovenous malformations

Tomoki Hashimoto, Yongqin Wu, Michael T. Lawton, Guo Yuan Yang, Nicholas Barbaro, William L. Young

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: Brain arteriovenous malformation (BAVMs) are structurally unstable blood vessels that display an angiogenic phenotype, possibly maintained by concerted effects of key angiogenic factors. Therefore, we hypothesized that there are close correlations among key angiogenic factors in BAVMs and that levels of key angiogenic factors are associated with BAVM clinical characteristics that are linked with vascular instability. METHODS: We measured the expression of angiopoietin-2 (Ang-2), matrix metalloproteinase-9, vascular endothelial growth factor (VEGF), and platelet-derived growth factor-AA and -BB by use of enzyme-linked immunosorbent assay in 27 BAVM surgical specimens. Tissues were also collected from 14 structurally normal brain specimens obtained during epilepsy surgery. RESULTS: Ang-2, VEGF, and matrix metalloproteinase-9 were highly expressed in BAVM samples (11.9 ± 15.5 ng/mg protein, 137 ± 102 pg/mg protein, and 379 ± 455 pg/mg protein, respectively). Platelet-derived growth factor-BB was detectable in 7 of 21 BAVM samples. There were close correlations between Ang-2 and VEGF (R2 = 0.79). Higher Ang-2 and VEGF levels seemed to be associated with draining vein characteristics linked with BAVM hemorrhage but not with feeding artery pressure or BAVM size. In the structurally normal brain specimens, levels of Ang-2, VEGF, and matrix metalloproteinase-9 were low (0.8 ± 2.3 ng/mg protein, 38 ± 25 pg/mg protein, and 52 ± 43 pg/mg protein, respectively). CONCLUSION: There were close correlations among angiogenic factors in BAVMs. Concerted effects of angiogenic factors may maintain the angiogenic phenotype in BAVMs and thereby determine the clinical course of BAVMs.

Original languageEnglish (US)
Pages (from-to)1058-1065
Number of pages8
JournalNeurosurgery
Volume56
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Angiogenesis Inducing Agents
Arteriovenous Malformations
Angiopoietin-2
Brain
Vascular Endothelial Growth Factor A
Matrix Metalloproteinase 9
Proteins
Blood Vessels
Phenotype
Veins
Epilepsy
Arteries
Enzyme-Linked Immunosorbent Assay

Keywords

  • Angiogenesis
  • Arteriovenous malformations
  • Endothelium
  • Growth factors/cytokines

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Hashimoto, T., Wu, Y., Lawton, M. T., Yang, G. Y., Barbaro, N., & Young, W. L. (2005). Coexpression of angiogenic factors in brain arteriovenous malformations. Neurosurgery, 56(5), 1058-1065. https://doi.org/10.1227/01.NEU.0000157925.19676.C3

Coexpression of angiogenic factors in brain arteriovenous malformations. / Hashimoto, Tomoki; Wu, Yongqin; Lawton, Michael T.; Yang, Guo Yuan; Barbaro, Nicholas; Young, William L.

In: Neurosurgery, Vol. 56, No. 5, 05.2005, p. 1058-1065.

Research output: Contribution to journalArticle

Hashimoto, T, Wu, Y, Lawton, MT, Yang, GY, Barbaro, N & Young, WL 2005, 'Coexpression of angiogenic factors in brain arteriovenous malformations', Neurosurgery, vol. 56, no. 5, pp. 1058-1065. https://doi.org/10.1227/01.NEU.0000157925.19676.C3
Hashimoto T, Wu Y, Lawton MT, Yang GY, Barbaro N, Young WL. Coexpression of angiogenic factors in brain arteriovenous malformations. Neurosurgery. 2005 May;56(5):1058-1065. https://doi.org/10.1227/01.NEU.0000157925.19676.C3
Hashimoto, Tomoki ; Wu, Yongqin ; Lawton, Michael T. ; Yang, Guo Yuan ; Barbaro, Nicholas ; Young, William L. / Coexpression of angiogenic factors in brain arteriovenous malformations. In: Neurosurgery. 2005 ; Vol. 56, No. 5. pp. 1058-1065.
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