Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness

Y. Yamanaka, H. Friess, M. S. Kobrin, M. Buchler, H. G. Beger, M. Korc

Research output: Contribution to journalArticle

380 Scopus citations

Abstract

Immunohistochemical analysis for the epidermal growth factor receptor (EGFR), EGF and transforming growth factor-alpha (TGF-α) was performed in 87 human pancreatic carcinomas. Expression frequencies for EGFR, EGF, and TGF-α were 43%, 46% and 54%, respectively. Coexpression of the receptor and at least one of its ligands occurred in 38% of the tumors, and correlated with large tumor size, advanced clinical staging, and decreased survival period. In situ hybridization revealed that the respective mRNAs were also overexpressed in the carcinomas. These findigs suggest that coexpression of EGFR and its ligands may contribute to the aggressiveness of human pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)565-570
Number of pages6
JournalAnticancer Research
Volume13
Issue number3
StatePublished - 1993

Keywords

  • Epidermal growth factor
  • Epidermal growth factor receptor
  • Human pancreatic cancer
  • Transforming growth factor alpha

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Yamanaka, Y., Friess, H., Kobrin, M. S., Buchler, M., Beger, H. G., & Korc, M. (1993). Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Research, 13(3), 565-570.