Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women

Atsushi Goto, Yiqing Song, Brian H. Chen, Joann E. Manson, Julie E. Buring, Simin Liu

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

OBJECTIVE: Coffee consumption has been inversely associated with type 2 diabetes risk, but its mechanisms are largely unknown. We aimed to examine whether plasma levels of sex hormones and sex hormone-binding globulin (SHBG) may account for the inverse association between coffee consumption and type 2 diabetes risk. RESEARCH DESIGN AND METHODS: We conducted a case-control study nested in the prospective Women's Health Study (WHS). During a median follow-up of 10 years, 359 postmenopausal women with newly diagnosed type 2 diabetes were matched with 359 control subjects by age, race, duration of follow-up, and time of blood draw. RESULTS: Caffeinated coffee was positively associated with SHBG but not with sex hormones. Multivariable-adjusted geometric mean levels of SHBG were 26.6 nmol/l among women consuming ≥4 cups/day of caffeinated coffee and 23.0 nmol/l among nondrinkers (P for trend = 0.01). In contrast, neither decaffeinated coffee nor tea was associated with SHBG or sex hormones. The multivariable-adjusted odds ratio (OR) of type 2 diabetes for women consuming ≥4 cups/day of caffeinated coffee compared with nondrinkers was 0.47 (95% CI 0.23- 0.94; P for trend ≥ 0.047). The association was largely attenuated after further adjusting for SHBG (OR 0.71 [95% CI 0.31-1.61]; P for trend ≥ 0.47). In addition, carriers of rs6259 minor allele and noncarriers of rs6257 minor allele of SHBG gene consuming ≥2 cups/day of caffeinated coffee had lower risk of type 2 diabetes in directions corresponding to their associated SHBG. CONCLUSIONS: Our findings suggest that SHBG may account for the inverse association between coffee consumption and type 2 diabetes risk among postmenopausal women.

Original languageEnglish (US)
Pages (from-to)269-275
Number of pages7
JournalDiabetes
Volume60
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

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Sex Hormone-Binding Globulin
Coffee
Caffeine
Type 2 Diabetes Mellitus
Gonadal Steroid Hormones
Alleles
Odds Ratio
Women's Health
Tea
Case-Control Studies
Research Design

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women. / Goto, Atsushi; Song, Yiqing; Chen, Brian H.; Manson, Joann E.; Buring, Julie E.; Liu, Simin.

In: Diabetes, Vol. 60, No. 1, 01.01.2011, p. 269-275.

Research output: Contribution to journalArticle

Goto, Atsushi ; Song, Yiqing ; Chen, Brian H. ; Manson, Joann E. ; Buring, Julie E. ; Liu, Simin. / Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women. In: Diabetes. 2011 ; Vol. 60, No. 1. pp. 269-275.
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