Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals

Dong Hang, Ane Sørlie Kværner, Wenjie Ma, Yang Hu, Fred K. Tabung, Hongmei Nan, Zhibin Hu, Hongbing Shen, Lorelei A. Mucci, Andrew T. Chan, Edward L. Giovannucci, Mingyang Song

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND: Coffee consumption has been linked to lower risk of various health outcomes. However, the biological pathways mediating the associations remain poorly understood. OBJECTIVES: The aim of this study was to assess the association between coffee consumption and concentrations of plasma biomarkers in key metabolic and inflammatory pathways underlying common chronic diseases. METHODS: We investigated the associations of total, caffeinated, and decaffeinated coffee consumption with 14 plasma biomarkers, including C-peptide, insulin-like growth factor 1 (IGF-1), IGF binding protein (IGFBP) 1, IGFBP-3, estrone, total and free estradiol, total and free testosterone, sex hormone-binding globulin (SHBG), total adiponectin, high-molecular-weight (HMW) adiponectin, leptin, C-reactive protein (CRP), interleukin 6 (IL-6), and soluble tumor necrosis factor receptor 2 (sTNFR-2). Data were derived from 2 cohorts of 15,551 women (Nurses' Health Study) and 7397 men (Health Professionals Follow-Up Study), who provided detailed dietary data before blood draw and were free of diabetes, cardiovascular disease, or cancer at the time of blood draw. Multivariable linear regression was used to calculate the percentage difference of biomarker concentrations comparing coffee drinkers with nondrinkers, after adjusting for a variety of demographic, clinical, and lifestyle factors. RESULTS: Compared with nondrinkers, participants who drank ≥4 cups of total coffee/d had lower concentrations of C-peptide (-8.7%), IGFBP-3 (-2.2%), estrone (-6.4%), total estradiol (-5.7%), free estradiol (-8.1%), leptin (-6.4%), CRP (-16.6%), IL-6 (-8.1%), and sTNFR-2 (-5.8%) and higher concentrations of SHBG (5.0%), total testosterone (7.3% in women and 5.3% in men), total adiponectin (9.3%), and HMW adiponectin (17.2%). The results were largely similar for caffeinated and decaffeinated coffee. CONCLUSION: Our data indicate that coffee consumption is associated with favorable profiles of numerous biomarkers in key metabolic and inflammatory pathways. This trial was registered at clinicaltrials.gov as NCT03419455.

Original languageEnglish (US)
Pages (from-to)635-647
Number of pages13
JournalThe American journal of clinical nutrition
Volume109
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Coffee
Metabolic Networks and Pathways
Biomarkers
Adiponectin
Health
Receptors, Tumor Necrosis Factor, Type II
Estradiol
Sex Hormone-Binding Globulin
Insulin-Like Growth Factor Binding Protein 3
Estrone
C-Peptide
Leptin
C-Reactive Protein
Testosterone
Interleukin-6
Molecular Weight
Men's Health
Insulin-Like Growth Factor Binding Protein 1
Women's Health
Somatomedins

Keywords

  • adipokine
  • coffee consumption
  • inflammation
  • insulin
  • sex hormone

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals. / Hang, Dong; Kværner, Ane Sørlie; Ma, Wenjie; Hu, Yang; Tabung, Fred K.; Nan, Hongmei; Hu, Zhibin; Shen, Hongbing; Mucci, Lorelei A.; Chan, Andrew T.; Giovannucci, Edward L.; Song, Mingyang.

In: The American journal of clinical nutrition, Vol. 109, No. 3, 01.03.2019, p. 635-647.

Research output: Contribution to journalArticle

Hang, D, Kværner, AS, Ma, W, Hu, Y, Tabung, FK, Nan, H, Hu, Z, Shen, H, Mucci, LA, Chan, AT, Giovannucci, EL & Song, M 2019, 'Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals', The American journal of clinical nutrition, vol. 109, no. 3, pp. 635-647. https://doi.org/10.1093/ajcn/nqy295
Hang, Dong ; Kværner, Ane Sørlie ; Ma, Wenjie ; Hu, Yang ; Tabung, Fred K. ; Nan, Hongmei ; Hu, Zhibin ; Shen, Hongbing ; Mucci, Lorelei A. ; Chan, Andrew T. ; Giovannucci, Edward L. ; Song, Mingyang. / Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals. In: The American journal of clinical nutrition. 2019 ; Vol. 109, No. 3. pp. 635-647.
@article{9798f4e40dc04d73893fda08069c6313,
title = "Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals",
abstract = "BACKGROUND: Coffee consumption has been linked to lower risk of various health outcomes. However, the biological pathways mediating the associations remain poorly understood. OBJECTIVES: The aim of this study was to assess the association between coffee consumption and concentrations of plasma biomarkers in key metabolic and inflammatory pathways underlying common chronic diseases. METHODS: We investigated the associations of total, caffeinated, and decaffeinated coffee consumption with 14 plasma biomarkers, including C-peptide, insulin-like growth factor 1 (IGF-1), IGF binding protein (IGFBP) 1, IGFBP-3, estrone, total and free estradiol, total and free testosterone, sex hormone-binding globulin (SHBG), total adiponectin, high-molecular-weight (HMW) adiponectin, leptin, C-reactive protein (CRP), interleukin 6 (IL-6), and soluble tumor necrosis factor receptor 2 (sTNFR-2). Data were derived from 2 cohorts of 15,551 women (Nurses' Health Study) and 7397 men (Health Professionals Follow-Up Study), who provided detailed dietary data before blood draw and were free of diabetes, cardiovascular disease, or cancer at the time of blood draw. Multivariable linear regression was used to calculate the percentage difference of biomarker concentrations comparing coffee drinkers with nondrinkers, after adjusting for a variety of demographic, clinical, and lifestyle factors. RESULTS: Compared with nondrinkers, participants who drank ≥4 cups of total coffee/d had lower concentrations of C-peptide (-8.7{\%}), IGFBP-3 (-2.2{\%}), estrone (-6.4{\%}), total estradiol (-5.7{\%}), free estradiol (-8.1{\%}), leptin (-6.4{\%}), CRP (-16.6{\%}), IL-6 (-8.1{\%}), and sTNFR-2 (-5.8{\%}) and higher concentrations of SHBG (5.0{\%}), total testosterone (7.3{\%} in women and 5.3{\%} in men), total adiponectin (9.3{\%}), and HMW adiponectin (17.2{\%}). The results were largely similar for caffeinated and decaffeinated coffee. CONCLUSION: Our data indicate that coffee consumption is associated with favorable profiles of numerous biomarkers in key metabolic and inflammatory pathways. This trial was registered at clinicaltrials.gov as NCT03419455.",
keywords = "adipokine, coffee consumption, inflammation, insulin, sex hormone",
author = "Dong Hang and Kv{\ae}rner, {Ane S{\o}rlie} and Wenjie Ma and Yang Hu and Tabung, {Fred K.} and Hongmei Nan and Zhibin Hu and Hongbing Shen and Mucci, {Lorelei A.} and Chan, {Andrew T.} and Giovannucci, {Edward L.} and Mingyang Song",
year = "2019",
month = "3",
day = "1",
doi = "10.1093/ajcn/nqy295",
language = "English (US)",
volume = "109",
pages = "635--647",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

TY - JOUR

T1 - Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals

AU - Hang, Dong

AU - Kværner, Ane Sørlie

AU - Ma, Wenjie

AU - Hu, Yang

AU - Tabung, Fred K.

AU - Nan, Hongmei

AU - Hu, Zhibin

AU - Shen, Hongbing

AU - Mucci, Lorelei A.

AU - Chan, Andrew T.

AU - Giovannucci, Edward L.

AU - Song, Mingyang

PY - 2019/3/1

Y1 - 2019/3/1

N2 - BACKGROUND: Coffee consumption has been linked to lower risk of various health outcomes. However, the biological pathways mediating the associations remain poorly understood. OBJECTIVES: The aim of this study was to assess the association between coffee consumption and concentrations of plasma biomarkers in key metabolic and inflammatory pathways underlying common chronic diseases. METHODS: We investigated the associations of total, caffeinated, and decaffeinated coffee consumption with 14 plasma biomarkers, including C-peptide, insulin-like growth factor 1 (IGF-1), IGF binding protein (IGFBP) 1, IGFBP-3, estrone, total and free estradiol, total and free testosterone, sex hormone-binding globulin (SHBG), total adiponectin, high-molecular-weight (HMW) adiponectin, leptin, C-reactive protein (CRP), interleukin 6 (IL-6), and soluble tumor necrosis factor receptor 2 (sTNFR-2). Data were derived from 2 cohorts of 15,551 women (Nurses' Health Study) and 7397 men (Health Professionals Follow-Up Study), who provided detailed dietary data before blood draw and were free of diabetes, cardiovascular disease, or cancer at the time of blood draw. Multivariable linear regression was used to calculate the percentage difference of biomarker concentrations comparing coffee drinkers with nondrinkers, after adjusting for a variety of demographic, clinical, and lifestyle factors. RESULTS: Compared with nondrinkers, participants who drank ≥4 cups of total coffee/d had lower concentrations of C-peptide (-8.7%), IGFBP-3 (-2.2%), estrone (-6.4%), total estradiol (-5.7%), free estradiol (-8.1%), leptin (-6.4%), CRP (-16.6%), IL-6 (-8.1%), and sTNFR-2 (-5.8%) and higher concentrations of SHBG (5.0%), total testosterone (7.3% in women and 5.3% in men), total adiponectin (9.3%), and HMW adiponectin (17.2%). The results were largely similar for caffeinated and decaffeinated coffee. CONCLUSION: Our data indicate that coffee consumption is associated with favorable profiles of numerous biomarkers in key metabolic and inflammatory pathways. This trial was registered at clinicaltrials.gov as NCT03419455.

AB - BACKGROUND: Coffee consumption has been linked to lower risk of various health outcomes. However, the biological pathways mediating the associations remain poorly understood. OBJECTIVES: The aim of this study was to assess the association between coffee consumption and concentrations of plasma biomarkers in key metabolic and inflammatory pathways underlying common chronic diseases. METHODS: We investigated the associations of total, caffeinated, and decaffeinated coffee consumption with 14 plasma biomarkers, including C-peptide, insulin-like growth factor 1 (IGF-1), IGF binding protein (IGFBP) 1, IGFBP-3, estrone, total and free estradiol, total and free testosterone, sex hormone-binding globulin (SHBG), total adiponectin, high-molecular-weight (HMW) adiponectin, leptin, C-reactive protein (CRP), interleukin 6 (IL-6), and soluble tumor necrosis factor receptor 2 (sTNFR-2). Data were derived from 2 cohorts of 15,551 women (Nurses' Health Study) and 7397 men (Health Professionals Follow-Up Study), who provided detailed dietary data before blood draw and were free of diabetes, cardiovascular disease, or cancer at the time of blood draw. Multivariable linear regression was used to calculate the percentage difference of biomarker concentrations comparing coffee drinkers with nondrinkers, after adjusting for a variety of demographic, clinical, and lifestyle factors. RESULTS: Compared with nondrinkers, participants who drank ≥4 cups of total coffee/d had lower concentrations of C-peptide (-8.7%), IGFBP-3 (-2.2%), estrone (-6.4%), total estradiol (-5.7%), free estradiol (-8.1%), leptin (-6.4%), CRP (-16.6%), IL-6 (-8.1%), and sTNFR-2 (-5.8%) and higher concentrations of SHBG (5.0%), total testosterone (7.3% in women and 5.3% in men), total adiponectin (9.3%), and HMW adiponectin (17.2%). The results were largely similar for caffeinated and decaffeinated coffee. CONCLUSION: Our data indicate that coffee consumption is associated with favorable profiles of numerous biomarkers in key metabolic and inflammatory pathways. This trial was registered at clinicaltrials.gov as NCT03419455.

KW - adipokine

KW - coffee consumption

KW - inflammation

KW - insulin

KW - sex hormone

UR - http://www.scopus.com/inward/record.url?scp=85062625261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062625261&partnerID=8YFLogxK

U2 - 10.1093/ajcn/nqy295

DO - 10.1093/ajcn/nqy295

M3 - Article

C2 - 30834441

AN - SCOPUS:85062625261

VL - 109

SP - 635

EP - 647

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -