Cognitive deficits and health-related quality of life in chronic heart failure

Susan Pressler, Usha Subramanian, David Kareken, Susan Perkins, Irmina Gradus-Pizlo, Mary Jane Sauvé, Yan Ding, JinShil Kim, Rebecca Sloan, Heather Jaynes, Rose M. Shaw

Research output: Contribution to journalArticle

66 Citations (Scopus)


BACKGROUND: Patients with chronic heart failure (HF) have cognitive deficits in memory, psychomotor speed, and executive function and poor health-related quality of life (HRQL), but the association between cognitive deficits and HRQL is unknown. OBJECTIVES: The objectives of this study were to (1) evaluate the relationship between HF severity, age, comorbidities, and cognitive deficits and HRQL among patients with chronic HF and (2) examine whether cognitive deficits mediated the relationship between HF severity and HRQL. DESIGN AND SAMPLE: This study was part of a larger explanatory study; 249 patients with HF completed face-to-face interviews. METHODS: Measures of HF severity, comorbidity (multiple comorbid conditions, hypertension, and depressive symptoms), cognitive function (domains of language, working memory, memory, psychomotor speed, and executive function), and HRQL were obtained. Clinical variables were abstracted from patients' records. Statistical analyses were conducted using descriptive statistics, Pearson correlation coefficients, and multiple linear regression analyses. RESULTS: Overall, the HRQL of patients was moderately poor. Heart failure severity, age, depressive symptoms, and total recall memory explained 55% of the variance in HRQL, but the contribution of memory was minimal (1%). Patients with more severe HF, younger age, and more depressive symptoms had poorer HRQL. Other cognitive function variables, multiple comorbidity, and hypertension were not significant explanatory variables for HRQL. Cognitive deficits did not mediate the relationship between HF severity and HRQL. CONCLUSIONS: Novel interventions targeted at improving HRQL continue to be urgently needed, particularly among younger patients and patients with depressive symptoms. Measures of HRQL are not sufficient as outcomes when investigating cognitive deficits in HF. Investigators need to include outcome measures of patients' actual abilities to perform daily activities and HF self-care.

Original languageEnglish
Pages (from-to)189-198
Number of pages10
JournalJournal of Cardiovascular Nursing
Issue number3
StatePublished - May 2010


Heart Failure
Quality of Life
Executive Function
Memory Disorders
Self Care
Short-Term Memory
Linear Models
Regression Analysis
Research Personnel
Outcome Assessment (Health Care)


  • Cognitive deficits
  • Cognitive impairment
  • Health-related quality of life
  • Heart failure
  • Quality of life

ASJC Scopus subject areas

  • Advanced and Specialized Nursing
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Cognitive deficits and health-related quality of life in chronic heart failure. / Pressler, Susan; Subramanian, Usha; Kareken, David; Perkins, Susan; Gradus-Pizlo, Irmina; Sauvé, Mary Jane; Ding, Yan; Kim, JinShil; Sloan, Rebecca; Jaynes, Heather; Shaw, Rose M.

In: Journal of Cardiovascular Nursing, Vol. 25, No. 3, 05.2010, p. 189-198.

Research output: Contribution to journalArticle

Pressler, S, Subramanian, U, Kareken, D, Perkins, S, Gradus-Pizlo, I, Sauvé, MJ, Ding, Y, Kim, J, Sloan, R, Jaynes, H & Shaw, RM 2010, 'Cognitive deficits and health-related quality of life in chronic heart failure', Journal of Cardiovascular Nursing, vol. 25, no. 3, pp. 189-198.
Pressler, Susan ; Subramanian, Usha ; Kareken, David ; Perkins, Susan ; Gradus-Pizlo, Irmina ; Sauvé, Mary Jane ; Ding, Yan ; Kim, JinShil ; Sloan, Rebecca ; Jaynes, Heather ; Shaw, Rose M. / Cognitive deficits and health-related quality of life in chronic heart failure. In: Journal of Cardiovascular Nursing. 2010 ; Vol. 25, No. 3. pp. 189-198.
title = "Cognitive deficits and health-related quality of life in chronic heart failure",
abstract = "Lippincott Williams & Wilkins.",
keywords = "Cognitive deficits, Cognitive impairment, Health-related quality of life, Heart failure, Quality of life",
author = "Susan Pressler and Usha Subramanian and David Kareken and Susan Perkins and Irmina Gradus-Pizlo and Sauv{\'e}, {Mary Jane} and Yan Ding and JinShil Kim and Rebecca Sloan and Heather Jaynes and Shaw, {Rose M.}",
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AU - Shaw, Rose M.

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