Cognitive effects of corticosteroids

Owen M. Wolkowitz, Victor I. Reus, Herbert Weingartner, Karen Thompson, Alan Breier, Allen Doran, David Rubinow, David Pickar

Research output: Contribution to journalArticle

343 Citations (Scopus)

Abstract

In three independent studies with different designs and groups of subjects, the authors found that 1) depressed patients who did not suppress cortisol when given dexamethasone (compared to suppressors and normal control subjects), 2) healthy volunteers given a single 1-mg dose of dexamethasone (compared to those given placebo), and 3) healthy volunteers given 80 mg/day of prednisone for 5 days (compared to those given placebo) all made significantly more errors of commission in verbal memory tasks, with no significant change in their rates of errors of omission. These findings raise the possibility of specific corticosteroid-related cognitive impairments.

Original languageEnglish (US)
Pages (from-to)1297-1303
Number of pages7
JournalAmerican Journal of Psychiatry
Volume147
Issue number10
DOIs
StatePublished - Jan 1 1990

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Dexamethasone
Healthy Volunteers
Adrenal Cortex Hormones
Placebos
Prednisone
Hydrocortisone
Cognitive Dysfunction

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Wolkowitz, O. M., Reus, V. I., Weingartner, H., Thompson, K., Breier, A., Doran, A., ... Pickar, D. (1990). Cognitive effects of corticosteroids. American Journal of Psychiatry, 147(10), 1297-1303. https://doi.org/10.1176/ajp.147.10.1297

Cognitive effects of corticosteroids. / Wolkowitz, Owen M.; Reus, Victor I.; Weingartner, Herbert; Thompson, Karen; Breier, Alan; Doran, Allen; Rubinow, David; Pickar, David.

In: American Journal of Psychiatry, Vol. 147, No. 10, 01.01.1990, p. 1297-1303.

Research output: Contribution to journalArticle

Wolkowitz, OM, Reus, VI, Weingartner, H, Thompson, K, Breier, A, Doran, A, Rubinow, D & Pickar, D 1990, 'Cognitive effects of corticosteroids', American Journal of Psychiatry, vol. 147, no. 10, pp. 1297-1303. https://doi.org/10.1176/ajp.147.10.1297
Wolkowitz OM, Reus VI, Weingartner H, Thompson K, Breier A, Doran A et al. Cognitive effects of corticosteroids. American Journal of Psychiatry. 1990 Jan 1;147(10):1297-1303. https://doi.org/10.1176/ajp.147.10.1297
Wolkowitz, Owen M. ; Reus, Victor I. ; Weingartner, Herbert ; Thompson, Karen ; Breier, Alan ; Doran, Allen ; Rubinow, David ; Pickar, David. / Cognitive effects of corticosteroids. In: American Journal of Psychiatry. 1990 ; Vol. 147, No. 10. pp. 1297-1303.
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