Cognitive effects of cytotoxic cancer chemotherapy: Predisposing risk factors and potential treatments

Thomas W. McAllister, Tim A. Ahles, Andrew J. Saykin, Robert J. Ferguson, Brenna C. McDonald, Lionel D. Lewis, Laura A. Flashman, C. Harker Rhodes

Research output: Contribution to journalReview article

41 Scopus citations


Increasing evidence suggests that systemic cancer chemotherapy can have significant long-term effects on cognition, particularly on verbal learning, memory, attention, and speed of information processing. These deficits can be a source of significant distress to survivors. There is much less known about the mechanisms, predisposing vulnerabilities, and treatment of these deficits. We will summarize current knowledge of chemotherapy-associated cognitive deficits. Emerging theories about the role of selected genetic polymorphisms in heightening the vulnerability to chemotherapy-induced cognitive decline will be described.

Original languageEnglish (US)
Pages (from-to)364-371
Number of pages8
JournalCurrent psychiatry reports
Issue number5
StatePublished - Oct 2004


ASJC Scopus subject areas

  • Psychiatry and Mental health

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