Cognitive effects of cytotoxic cancer chemotherapy: Predisposing risk factors and potential treatments

Thomas W. McAllister, Tim A. Ahles, Andrew Saykin, Robert J. Ferguson, Brenna McDonald, Lionel D. Lewis, Laura A. Flashman, C. Harker Rhodes

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Increasing evidence suggests that systemic cancer chemotherapy can have significant long-term effects on cognition, particularly on verbal learning, memory, attention, and speed of information processing. These deficits can be a source of significant distress to survivors. There is much less known about the mechanisms, predisposing vulnerabilities, and treatment of these deficits. We will summarize current knowledge of chemotherapy-associated cognitive deficits. Emerging theories about the role of selected genetic polymorphisms in heightening the vulnerability to chemotherapy-induced cognitive decline will be described.

Original languageEnglish (US)
Pages (from-to)364-371
Number of pages8
JournalCurrent Psychiatry Reports
Volume6
Issue number5
StatePublished - Oct 2004
Externally publishedYes

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Causality
Drug Therapy
Verbal Learning
Neoplasms
Genetic Polymorphisms
Automatic Data Processing
Cognition
Therapeutics
Cognitive Dysfunction

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

McAllister, T. W., Ahles, T. A., Saykin, A., Ferguson, R. J., McDonald, B., Lewis, L. D., ... Rhodes, C. H. (2004). Cognitive effects of cytotoxic cancer chemotherapy: Predisposing risk factors and potential treatments. Current Psychiatry Reports, 6(5), 364-371.

Cognitive effects of cytotoxic cancer chemotherapy : Predisposing risk factors and potential treatments. / McAllister, Thomas W.; Ahles, Tim A.; Saykin, Andrew; Ferguson, Robert J.; McDonald, Brenna; Lewis, Lionel D.; Flashman, Laura A.; Rhodes, C. Harker.

In: Current Psychiatry Reports, Vol. 6, No. 5, 10.2004, p. 364-371.

Research output: Contribution to journalArticle

McAllister, TW, Ahles, TA, Saykin, A, Ferguson, RJ, McDonald, B, Lewis, LD, Flashman, LA & Rhodes, CH 2004, 'Cognitive effects of cytotoxic cancer chemotherapy: Predisposing risk factors and potential treatments', Current Psychiatry Reports, vol. 6, no. 5, pp. 364-371.
McAllister, Thomas W. ; Ahles, Tim A. ; Saykin, Andrew ; Ferguson, Robert J. ; McDonald, Brenna ; Lewis, Lionel D. ; Flashman, Laura A. ; Rhodes, C. Harker. / Cognitive effects of cytotoxic cancer chemotherapy : Predisposing risk factors and potential treatments. In: Current Psychiatry Reports. 2004 ; Vol. 6, No. 5. pp. 364-371.
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