Cognitive function, body mass index and mortality in a rural elderly Chinese cohort

Sujuan Gao, Yinlong Jin, Frederick Unverzagt, Yibin Cheng, Liqin Su, Chenkun Wang, Feng Ma, Ann Hake, Carla Kettler, Chen Chen, Jingyi Liu, Jianchao Bian, Ping Li, Jill R. Murrell, Daniel Clark, Hugh Hendrie

Research output: Contribution to journalArticle

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Abstract

Background: Previous studies have shown that poor cognition and low body mass index were associated with increased mortality. But few studies have investigated the association between cognition and mortality across the entire cognitive spectrum while adjusting for BMI. The objective of this study is to examine the associations between cognitive function, BMI and 7-year mortality in a rural elderly Chinese cohort. Methods: A prospective cohort of 2,000 Chinese age 65 and over from four rural counties in China were followed for 7-years. Cognitive function, BMI and other covariate information were obtained at baseline. Cox's proportional hazard models were used to determine the effects of cognitive function and BMI on mortality risk. Results: Of participants enrolled, 473 (23.7%) died during follow-up. Both lower cognitive function (HR = 1.48, p = 0.0049) and lower BMI (HR = 1.6, p < 0.0001) were independently associated with increased mortality risk compared to individuals with average cognitive function and normal weight. Higher cognitive function was associated with lower mortality risk (HR = 0.69, p = 0.0312). We found no significant difference in mortality risk between overweight/obese participants and those with normal weight. Conclusions: Cognitive function and BMI were independent predictors of mortality risk. Intervention strategies for increasing cognitive function and maintaining adequate BMI may be important in reducing morality risk in the elderly population.

Original languageEnglish (US)
Article number9
JournalArchives of Public Health
Volume72
Issue number1
DOIs
StatePublished - 2014

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Cognition
Body Mass Index
Mortality
Weights and Measures
Proportional Hazards Models
China

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Cognitive function, body mass index and mortality in a rural elderly Chinese cohort. / Gao, Sujuan; Jin, Yinlong; Unverzagt, Frederick; Cheng, Yibin; Su, Liqin; Wang, Chenkun; Ma, Feng; Hake, Ann; Kettler, Carla; Chen, Chen; Liu, Jingyi; Bian, Jianchao; Li, Ping; Murrell, Jill R.; Clark, Daniel; Hendrie, Hugh.

In: Archives of Public Health, Vol. 72, No. 1, 9, 2014.

Research output: Contribution to journalArticle

Gao, Sujuan ; Jin, Yinlong ; Unverzagt, Frederick ; Cheng, Yibin ; Su, Liqin ; Wang, Chenkun ; Ma, Feng ; Hake, Ann ; Kettler, Carla ; Chen, Chen ; Liu, Jingyi ; Bian, Jianchao ; Li, Ping ; Murrell, Jill R. ; Clark, Daniel ; Hendrie, Hugh. / Cognitive function, body mass index and mortality in a rural elderly Chinese cohort. In: Archives of Public Health. 2014 ; Vol. 72, No. 1.
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abstract = "Background: Previous studies have shown that poor cognition and low body mass index were associated with increased mortality. But few studies have investigated the association between cognition and mortality across the entire cognitive spectrum while adjusting for BMI. The objective of this study is to examine the associations between cognitive function, BMI and 7-year mortality in a rural elderly Chinese cohort. Methods: A prospective cohort of 2,000 Chinese age 65 and over from four rural counties in China were followed for 7-years. Cognitive function, BMI and other covariate information were obtained at baseline. Cox's proportional hazard models were used to determine the effects of cognitive function and BMI on mortality risk. Results: Of participants enrolled, 473 (23.7{\%}) died during follow-up. Both lower cognitive function (HR = 1.48, p = 0.0049) and lower BMI (HR = 1.6, p < 0.0001) were independently associated with increased mortality risk compared to individuals with average cognitive function and normal weight. Higher cognitive function was associated with lower mortality risk (HR = 0.69, p = 0.0312). We found no significant difference in mortality risk between overweight/obese participants and those with normal weight. Conclusions: Cognitive function and BMI were independent predictors of mortality risk. Intervention strategies for increasing cognitive function and maintaining adequate BMI may be important in reducing morality risk in the elderly population.",
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AU - Ma, Feng

AU - Hake, Ann

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AU - Murrell, Jill R.

AU - Clark, Daniel

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