Cognitive Functioning and Neuroanatomic Volume Measures in Schizophrenia

David A. Kareken, Ruben C. Gur, P. David Mozley, Lyn H. Mozley, Andrew J. Saykin, Derri L. Shtasel, Raquel E. Gur

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Magnetic resonance imaging (MRI) and neuropsychological tests were administered to 68 patients with schizophrenia and 68 healthy controls. MRIs were analyzed with a partially automated segmentation method that quantifies the volume of each cerebral hemisphere and its cerebrospinal fluid (CSF). Whereas patients had higher ventricular-brain ratio (VBR), ventricular CSF (vCSF) volume was equivalent to controls. Brain volume was lower. Cognitive function did not correlate with VBR or vCSF volume in either group, but cognitive function did correlated with brain volume. Divided as deficit (DF) and nondeficit (NDF), only DF patients had lower brain volume than controls. Whereas NDF patients showed little correlation between anatomy and cognitive function, there were more correlations between brain volume and cognition in DF patients. Changes in DF/NDF subtype with time and treatment reduced the significance of these findings.

Original languageEnglish (US)
Pages (from-to)211-219
Number of pages9
Issue number2
StatePublished - Apr 1995
Externally publishedYes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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