Cognitive impairment in schizophrenia

A life span perspective

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cognitive impairment is a core Feature oF schizophrenia. The evolution oF cognitive impairment over the liFe span may clariFy whether schizophrenia is best characterized as a neurodevelopmental or neurodegenerative disorder. Children who later develop schizophrenia show delayed language acquisition, intellectual impairment, and poorer academic perFormance than peers. These premorbid intellectual deFicits may worsen beFore illness onset. Although patients show pervasive intellectual impairment at First episode, this deFicit does not appear to worsen through middle age. Gerontological patients remain poorly characterized, but a subset oF chronic, institutionalized patients may show Further intellectual and Functional decline in old age. From a cognitive perspective, schizophrenia may be best viewed as a neurodevelopmental disorder initiated by genetic or environmental Factors in the prenatal period. These early changes may contribute to premorbid cognitive impairment and to subsequent disturbances oF neural connectivity and transmission.

Original languageEnglish
Pages (from-to)398-405
Number of pages8
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Volume22
Issue number5
DOIs
StatePublished - Oct 2007

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Schizophrenia
Synaptic Transmission
Neurodegenerative Diseases
Language
Cognitive Dysfunction
Neurodevelopmental Disorders

Keywords

  • Cognition
  • Course
  • Neurodevelopment
  • Schizophrenia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Cognitive impairment in schizophrenia : A life span perspective. / O'Donnell, Brian.

In: American Journal of Alzheimer's Disease and other Dementias, Vol. 22, No. 5, 10.2007, p. 398-405.

Research output: Contribution to journalArticle

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