Cognitive rehabilitation interventions for executive function: Moving from bench to bedside in patients with traumatic brain injury

Keith Cicerone, Harvey Levin, James Malec, Donald Stuss, John Whyte, Emmeline Edwards

Research output: Contribution to journalReview article

180 Scopus citations

Abstract

Executive function mediated by prefrontally driven distributed networks is frequently impaired by traumatic brain injury (TBI) as a result of diffuse axonal injury and focal lesions. In addition to executive cognitive functions such as planning and working memory, the effects of TBI impact social cognition and motivation processes. To encourage application of cognitive neuroscience methods to studying recovery from TBI, associated reorganization of function, and development of interventions, this article reviews the pathophysiology of TBI, critiques currently employed methods of assessing executive function, and evaluates promising interventions that reflect advances in cognitive neuroscience. Brain imaging to identify neural mechanisms mediating executive dysfunction and response to interventions following TBI is also discussed.

Original languageEnglish (US)
Pages (from-to)1212-1222
Number of pages11
JournalJournal of Cognitive Neuroscience
Volume18
Issue number7
DOIs
StatePublished - Jul 21 2006

ASJC Scopus subject areas

  • Cognitive Neuroscience

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