Colonic strictures in children with cystic fibrosis

J. Michael Zerin, Jeanette Kuhn-Fulton, Susan J. White, Sonny K F Chong, John Stevens, Karen W. West, Daniel H. Teitelbaum, Samya Z. Nasr

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

PURPOSE: To determine the radiographic, clinical, surgical, and histologic findings in children with cystic fibrosis who develop strictures of the colon. MATERIALS AND METHODS: Ten children (five boys, five girls; age range, 2.5-9.0 years; mean age, 5.5 years), who were treated at the practices of the authors, were retrospectively identified and their medical records reviewed. RESULTS: Radiographic manifestations of the colonic disease included mucosal irregularity and spiculation with nodular thickening of the colonic wall and loss of normal colonic haustration. Luminal narrowing involved long segments of the colon. Longitudinal shortening of the colon was also a prominent feature. The decrease in caliber of the bowel ranged from mild narrowing to complete occlusion of the lumen. Histologic examination revealed severe submucosal fibrosis and fatty infiltration with transmural extension of the fibrosis to involve the serosa in some cases. Unlike in Crohn disease, however, acute inflammatory changes were minimal or absent. CONCLUSION: Colonic stricture in children with cyclic fibrosis is due to irreversible and frequently progressive narrowing of the colonic lumen.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalRadiology
Volume194
Issue number1
StatePublished - Jan 1995

Fingerprint

Cystic Fibrosis
Pathologic Constriction
Colon
Fibrosis
Colonic Diseases
Serous Membrane
Crohn Disease
Medical Records

Keywords

  • Colon, stenosis or obstruction
  • Fibrosis, cystic
  • Intestines, diseases

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Zerin, J. M., Kuhn-Fulton, J., White, S. J., Chong, S. K. F., Stevens, J., West, K. W., ... Nasr, S. Z. (1995). Colonic strictures in children with cystic fibrosis. Radiology, 194(1), 223-226.

Colonic strictures in children with cystic fibrosis. / Zerin, J. Michael; Kuhn-Fulton, Jeanette; White, Susan J.; Chong, Sonny K F; Stevens, John; West, Karen W.; Teitelbaum, Daniel H.; Nasr, Samya Z.

In: Radiology, Vol. 194, No. 1, 01.1995, p. 223-226.

Research output: Contribution to journalArticle

Zerin, JM, Kuhn-Fulton, J, White, SJ, Chong, SKF, Stevens, J, West, KW, Teitelbaum, DH & Nasr, SZ 1995, 'Colonic strictures in children with cystic fibrosis', Radiology, vol. 194, no. 1, pp. 223-226.
Zerin JM, Kuhn-Fulton J, White SJ, Chong SKF, Stevens J, West KW et al. Colonic strictures in children with cystic fibrosis. Radiology. 1995 Jan;194(1):223-226.
Zerin, J. Michael ; Kuhn-Fulton, Jeanette ; White, Susan J. ; Chong, Sonny K F ; Stevens, John ; West, Karen W. ; Teitelbaum, Daniel H. ; Nasr, Samya Z. / Colonic strictures in children with cystic fibrosis. In: Radiology. 1995 ; Vol. 194, No. 1. pp. 223-226.
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AU - Teitelbaum, Daniel H.

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N2 - PURPOSE: To determine the radiographic, clinical, surgical, and histologic findings in children with cystic fibrosis who develop strictures of the colon. MATERIALS AND METHODS: Ten children (five boys, five girls; age range, 2.5-9.0 years; mean age, 5.5 years), who were treated at the practices of the authors, were retrospectively identified and their medical records reviewed. RESULTS: Radiographic manifestations of the colonic disease included mucosal irregularity and spiculation with nodular thickening of the colonic wall and loss of normal colonic haustration. Luminal narrowing involved long segments of the colon. Longitudinal shortening of the colon was also a prominent feature. The decrease in caliber of the bowel ranged from mild narrowing to complete occlusion of the lumen. Histologic examination revealed severe submucosal fibrosis and fatty infiltration with transmural extension of the fibrosis to involve the serosa in some cases. Unlike in Crohn disease, however, acute inflammatory changes were minimal or absent. CONCLUSION: Colonic stricture in children with cyclic fibrosis is due to irreversible and frequently progressive narrowing of the colonic lumen.

AB - PURPOSE: To determine the radiographic, clinical, surgical, and histologic findings in children with cystic fibrosis who develop strictures of the colon. MATERIALS AND METHODS: Ten children (five boys, five girls; age range, 2.5-9.0 years; mean age, 5.5 years), who were treated at the practices of the authors, were retrospectively identified and their medical records reviewed. RESULTS: Radiographic manifestations of the colonic disease included mucosal irregularity and spiculation with nodular thickening of the colonic wall and loss of normal colonic haustration. Luminal narrowing involved long segments of the colon. Longitudinal shortening of the colon was also a prominent feature. The decrease in caliber of the bowel ranged from mild narrowing to complete occlusion of the lumen. Histologic examination revealed severe submucosal fibrosis and fatty infiltration with transmural extension of the fibrosis to involve the serosa in some cases. Unlike in Crohn disease, however, acute inflammatory changes were minimal or absent. CONCLUSION: Colonic stricture in children with cyclic fibrosis is due to irreversible and frequently progressive narrowing of the colonic lumen.

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