Colorectal adenocarcinoma as a second malignant neoplasm following Wilms' tumor and rhabdomyosarcoma

Tamara L. Densmore, Jacob C. Langer, Jean Molleston, Louis P. Dehner, Cheryl M. Coffin

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Colorectal carcinoma is one of the most common primary malignancies in adults and occurs in older patients after pelvic radiation. It is rare in children and young adults. We report two cases of colonic adenocarcinoma which were second malignant neoplasms following treatment for early childhood malignancies. One child had Wilms' tumor at 9 months of age treated with preoperative radiation and surgery. He developed radiation colitis and multifocal intestinal adenocarcinomas 42 years later and died with abdominal carcinomatosis. The second child had retroperitoneal embryonal rhabdomyosarcoma at age 1 year and was treated with preoperative radiation, surgery, and chemotherapy. At age 2 years he had radiation colitis; at age 11 years he had rectal adenocarcinoma associated with adenomatous polyps, focal adenomatous change and radiation colitis. Immunohistochemical studies revealed p53 positivity in both adenocarcinomas and in adenomas from the second patient, suggesting that p53 mutation was involved in carcinogenesis. The history of high dose radiation in early childhood and the multifocal lesions suggest the adenocarcinomas in both patients were second malignant neoplasms, with associated reactive and benign neoplastic and premalignant lesions well documented in one case. These two cases document the phenomenon of early onset of adult type tumors in survivors of childhood cancer and emphasize the need for continued clinical evaluation of patients at risk for second malignant neoplasms.

Original languageEnglish (US)
Pages (from-to)556-560
Number of pages5
JournalMedical and Pediatric Oncology
Volume27
Issue number6
DOIs
StatePublished - Dec 1996
Externally publishedYes

Fingerprint

Second Primary Neoplasms
Wilms Tumor
Rhabdomyosarcoma
Adenocarcinoma
Radiation
Colitis
Neoplasms
Embryonal Rhabdomyosarcoma
Adenomatous Polyps
Adenoma
Survivors
Young Adult
Colorectal Neoplasms
Carcinogenesis
History
Carcinoma
Drug Therapy
Mutation

Keywords

  • colorectal carcinoma
  • p53 mutation
  • radiation enteritis
  • radiation- induced neoplasms
  • second primary malignant neoplasm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

Cite this

Colorectal adenocarcinoma as a second malignant neoplasm following Wilms' tumor and rhabdomyosarcoma. / Densmore, Tamara L.; Langer, Jacob C.; Molleston, Jean; Dehner, Louis P.; Coffin, Cheryl M.

In: Medical and Pediatric Oncology, Vol. 27, No. 6, 12.1996, p. 556-560.

Research output: Contribution to journalArticle

Densmore, Tamara L. ; Langer, Jacob C. ; Molleston, Jean ; Dehner, Louis P. ; Coffin, Cheryl M. / Colorectal adenocarcinoma as a second malignant neoplasm following Wilms' tumor and rhabdomyosarcoma. In: Medical and Pediatric Oncology. 1996 ; Vol. 27, No. 6. pp. 556-560.
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