Combination alprazolam-neuroleptic treatment of the positive and negative symptoms of schizophrenia

O. M. Wolkowitz, D. Pickar, A. R. Doran, A. Breier, J. Tarell, S. M. Paul

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33 Scopus citations


Alprazolam, when added under double-blind conditions to a stable neuroleptic regimen in two patients with schizophrenia, resulted in clinically apparent improvement in positive and negative schizophrenic symptoms. Both patients showed significant worsening of symptoms following reduction of discontinuation of alprazolam.

Original languageEnglish (US)
Pages (from-to)85-87
Number of pages3
JournalAmerican Journal of Psychiatry
Issue number1
StatePublished - Jan 1 1986


ASJC Scopus subject areas

  • Psychiatry and Mental health

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