Combination chemotherapy with 5 day continuous infusion 5 fluorouracil (5 FU) and methyl CCNU in disseminated enteric adenocarcinoma

Lawrence Einhorn, B. E. Furnas, W. H. Bond, R. J. Rohn

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Thirty four patients (median age 59; range 24 to 77) with far advanced gastrointestinal neoplasms (colorectal 24, pancreas 6, stomach 2, and hepatoma 2) were treated with combined 5 FU 800 mg/M2 as a continuous 24 hr IV infusion in 1,000 cc D5W for 5 consecutive days and Methyl CCNU 150 mg/M2 p.o. on the first day of the 5 FU infusion. Three courses were given at 4 wk intervals; then maintenance chemotherapy consisted of oral weekly 5 FU (500 to 1000 mg) and Methyl CCNU, 125 mg/M2 p.o. every 4 wk. Partial remissions were observed in 7 of 25 colorectal cancers (median duration 6 mth; range 3 to 9+ mth), 1 of 6 pancreatic (duration 4 mth), 1 of 2 hepatomas (duration 4 mth), and 0 of 2 stomach cancers. There were 6 of 13 responses in female patients, and only 3 of 21 responses in male patients. Toxicity was minimal and consisted of mild nausea and vomiting and myelosuppression. Myelosuppression was minimal during the first 3 mth of therapy, with the median lowest granulocyte count 2,500 and only 6 patients and platelet counts below 100,000. There was only one episode of granulocytopenia related sepsis and no episodes of thrombocytopenia related bleeding.

Original languageEnglish
Title of host publicationProceedings of the American Association for Cancer Research
Volume16
Edition66
StatePublished - 1975

ASJC Scopus subject areas

  • Medicine(all)

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    Einhorn, L., Furnas, B. E., Bond, W. H., & Rohn, R. J. (1975). Combination chemotherapy with 5 day continuous infusion 5 fluorouracil (5 FU) and methyl CCNU in disseminated enteric adenocarcinoma. In Proceedings of the American Association for Cancer Research (66 ed., Vol. 16)