Thirty four patients (median age 59; range 24 to 77) with far advanced gastrointestinal neoplasms (colorectal 24, pancreas 6, stomach 2, and hepatoma 2) were treated with combined 5 FU 800 mg/M2 as a continuous 24 hr IV infusion in 1,000 cc D5W for 5 consecutive days and Methyl CCNU 150 mg/M2 p.o. on the first day of the 5 FU infusion. Three courses were given at 4 wk intervals; then maintenance chemotherapy consisted of oral weekly 5 FU (500 to 1000 mg) and Methyl CCNU, 125 mg/M2 p.o. every 4 wk. Partial remissions were observed in 7 of 25 colorectal cancers (median duration 6 mth; range 3 to 9+ mth), 1 of 6 pancreatic (duration 4 mth), 1 of 2 hepatomas (duration 4 mth), and 0 of 2 stomach cancers. There were 6 of 13 responses in female patients, and only 3 of 21 responses in male patients. Toxicity was minimal and consisted of mild nausea and vomiting and myelosuppression. Myelosuppression was minimal during the first 3 mth of therapy, with the median lowest granulocyte count 2,500 and only 6 patients and platelet counts below 100,000. There was only one episode of granulocytopenia related sepsis and no episodes of thrombocytopenia related bleeding.
|Title of host publication||Proceedings of the American Association for Cancer Research|
|State||Published - 1975|
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