Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty

Keith L. March, Tony J. Spaedy, Michael Aita, Robert L. Wilensky, Ionina Gradus-Pizlo, David R. Hathaway

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Smooth muscle cell proliferation plays a major role in restenosis following angioplasty. We have studied the effects of ultraviolet A (UVA) activation of 8-methoxypsoralen (8-MOP) on cultured SMC as well as atherosclerotic rabbit femoral arteries following angioplasty. 8-MOP and UVA display synergistic proliferation inhibition of cultured SMC in a cell-cycle independent manner. At intermediate doses, a cytostatic effect was seen over a 28 day period following a single exposure. In conclusion, a combination of 8-MOP and UVA significantly lowered SMC proliferation and cellularity in cell culture as well as in the neointima and media after balloon-induced vascular injury in the atherosclerotic rabbit model. This approach of systemic administration and local activation is feasible and offers a potential therapy for restenosis.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsGeorge S. Abela
Pages11-24
Number of pages14
StatePublished - Dec 1 1994
EventProceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV - Los Angeles, CA, USA
Duration: Jan 22 1994Jan 23 1994

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2130
ISSN (Print)0277-786X

Other

OtherProceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV
CityLos Angeles, CA, USA
Period1/22/941/23/94

    Fingerprint

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

March, K. L., Spaedy, T. J., Aita, M., Wilensky, R. L., Gradus-Pizlo, I., & Hathaway, D. R. (1994). Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty. In G. S. Abela (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 11-24). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2130).