Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty

Keith L. March, Tony J. Spaedy, Michael Aita, Robert L. Wilensky, Ionina Gradus-Pizlo, David R. Hathaway

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Smooth muscle cell proliferation plays a major role in restenosis following angioplasty. We have studied the effects of ultraviolet A (UVA) activation of 8-methoxypsoralen (8-MOP) on cultured SMC as well as atherosclerotic rabbit femoral arteries following angioplasty. 8-MOP and UVA display synergistic proliferation inhibition of cultured SMC in a cell-cycle independent manner. At intermediate doses, a cytostatic effect was seen over a 28 day period following a single exposure. In conclusion, a combination of 8-MOP and UVA significantly lowered SMC proliferation and cellularity in cell culture as well as in the neointima and media after balloon-induced vascular injury in the atherosclerotic rabbit model. This approach of systemic administration and local activation is feasible and offers a potential therapy for restenosis.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsGeorge S. Abela
Pages11-24
Number of pages14
Volume2130
StatePublished - 1994
EventProceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV - Los Angeles, CA, USA
Duration: Jan 22 1994Jan 23 1994

Other

OtherProceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV
CityLos Angeles, CA, USA
Period1/22/941/23/94

Fingerprint

smooth muscle
rabbits
Muscle
Chemical activation
activation
muscle cells
Balloons
Cell proliferation
balloons
arteries
Cell culture
therapy
Cells
dosage
cycles

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

March, K. L., Spaedy, T. J., Aita, M., Wilensky, R. L., Gradus-Pizlo, I., & Hathaway, D. R. (1994). Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty. In G. S. Abela (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2130, pp. 11-24)

Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty. / March, Keith L.; Spaedy, Tony J.; Aita, Michael; Wilensky, Robert L.; Gradus-Pizlo, Ionina; Hathaway, David R.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / George S. Abela. Vol. 2130 1994. p. 11-24.

Research output: Chapter in Book/Report/Conference proceedingChapter

March, KL, Spaedy, TJ, Aita, M, Wilensky, RL, Gradus-Pizlo, I & Hathaway, DR 1994, Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty. in GS Abela (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2130, pp. 11-24, Proceedings of Diagnostic and Therapeutic Cardiovascular Interventions IV, Los Angeles, CA, USA, 1/22/94.
March KL, Spaedy TJ, Aita M, Wilensky RL, Gradus-Pizlo I, Hathaway DR. Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty. In Abela GS, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2130. 1994. p. 11-24
March, Keith L. ; Spaedy, Tony J. ; Aita, Michael ; Wilensky, Robert L. ; Gradus-Pizlo, Ionina ; Hathaway, David R. / Combination of 8-methoxypsoralen and ultraviolet A inhibits smooth muscle proliferation in vitro and in vivo after angioplasty. Proceedings of SPIE - The International Society for Optical Engineering. editor / George S. Abela. Vol. 2130 1994. pp. 11-24
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