Combinatorial transcriptional interaction within the cardiac neural crest

A pair of HANDs in heart formation

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The cardiac neural crest cells migrate from the rostral dorsal neural folds and populate the branchial arches, which contribute directly to the cardiac-outflow structures. Although neural crest cell specification is associated with a number of morphogenic factors, little is understood about the mechanisms by which transcription factors actually implement the transcriptional programs that dictate cell migration and later the differentiation into the proper cell types within the great vessels and the heart. It is clear from genetic evidence that members of the paired box family and basic helix-loop-helix (bHLH) transcription factors from the twist family of proteins are expressed in and play an important function in cardiac neural crest specification and differentiation. Interestingly, both paired box and bHLH factors can function as dimers and, in the case of twist family bHLH factors, partner choice can clearly dictate a change in transcriptional program. The focus of this review is to consider what role the protein-protein interactions of these transcription factors may play in determining cardiac neural crest specification and differentiation, and how genetic alteration of transcription factor stoichiometry within the cell may reflect more than a simple null event.

Original languageEnglish
Pages (from-to)151-161
Number of pages11
JournalBirth Defects Research Part C - Embryo Today: Reviews
Volume72
Issue number2
DOIs
StatePublished - Jun 2004

Fingerprint

Neural Crest
Transcription Factors
Twist-Related Protein 1
Genetic Transcription
Branchial Region
Basic Helix-Loop-Helix Transcription Factors
Cell Movement
Proteins

ASJC Scopus subject areas

  • Embryology

Cite this

@article{5fd506c030ca4cb58c737e374f4c5d26,
title = "Combinatorial transcriptional interaction within the cardiac neural crest: A pair of HANDs in heart formation",
abstract = "The cardiac neural crest cells migrate from the rostral dorsal neural folds and populate the branchial arches, which contribute directly to the cardiac-outflow structures. Although neural crest cell specification is associated with a number of morphogenic factors, little is understood about the mechanisms by which transcription factors actually implement the transcriptional programs that dictate cell migration and later the differentiation into the proper cell types within the great vessels and the heart. It is clear from genetic evidence that members of the paired box family and basic helix-loop-helix (bHLH) transcription factors from the twist family of proteins are expressed in and play an important function in cardiac neural crest specification and differentiation. Interestingly, both paired box and bHLH factors can function as dimers and, in the case of twist family bHLH factors, partner choice can clearly dictate a change in transcriptional program. The focus of this review is to consider what role the protein-protein interactions of these transcription factors may play in determining cardiac neural crest specification and differentiation, and how genetic alteration of transcription factor stoichiometry within the cell may reflect more than a simple null event.",
author = "Anthony Firulli and Simon Conway",
year = "2004",
month = "6",
doi = "10.1002/bdrc.20009",
language = "English",
volume = "72",
pages = "151--161",
journal = "Birth Defects Research Part C - Embryo Today: Reviews",
issn = "1542-975X",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Combinatorial transcriptional interaction within the cardiac neural crest

T2 - A pair of HANDs in heart formation

AU - Firulli, Anthony

AU - Conway, Simon

PY - 2004/6

Y1 - 2004/6

N2 - The cardiac neural crest cells migrate from the rostral dorsal neural folds and populate the branchial arches, which contribute directly to the cardiac-outflow structures. Although neural crest cell specification is associated with a number of morphogenic factors, little is understood about the mechanisms by which transcription factors actually implement the transcriptional programs that dictate cell migration and later the differentiation into the proper cell types within the great vessels and the heart. It is clear from genetic evidence that members of the paired box family and basic helix-loop-helix (bHLH) transcription factors from the twist family of proteins are expressed in and play an important function in cardiac neural crest specification and differentiation. Interestingly, both paired box and bHLH factors can function as dimers and, in the case of twist family bHLH factors, partner choice can clearly dictate a change in transcriptional program. The focus of this review is to consider what role the protein-protein interactions of these transcription factors may play in determining cardiac neural crest specification and differentiation, and how genetic alteration of transcription factor stoichiometry within the cell may reflect more than a simple null event.

AB - The cardiac neural crest cells migrate from the rostral dorsal neural folds and populate the branchial arches, which contribute directly to the cardiac-outflow structures. Although neural crest cell specification is associated with a number of morphogenic factors, little is understood about the mechanisms by which transcription factors actually implement the transcriptional programs that dictate cell migration and later the differentiation into the proper cell types within the great vessels and the heart. It is clear from genetic evidence that members of the paired box family and basic helix-loop-helix (bHLH) transcription factors from the twist family of proteins are expressed in and play an important function in cardiac neural crest specification and differentiation. Interestingly, both paired box and bHLH factors can function as dimers and, in the case of twist family bHLH factors, partner choice can clearly dictate a change in transcriptional program. The focus of this review is to consider what role the protein-protein interactions of these transcription factors may play in determining cardiac neural crest specification and differentiation, and how genetic alteration of transcription factor stoichiometry within the cell may reflect more than a simple null event.

UR - http://www.scopus.com/inward/record.url?scp=3843120174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3843120174&partnerID=8YFLogxK

U2 - 10.1002/bdrc.20009

DO - 10.1002/bdrc.20009

M3 - Article

VL - 72

SP - 151

EP - 161

JO - Birth Defects Research Part C - Embryo Today: Reviews

JF - Birth Defects Research Part C - Embryo Today: Reviews

SN - 1542-975X

IS - 2

ER -