Combinatorial treatments enhance recovery following facial nerve crush

Nijee Sharma, Carl W. Moeller, Sam J. Marzo, Kathryn Jones, Eileen M. Foecking

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives/Hypothesis: To investigate the effects of various combinatorial treatments, consisting of a tapering dose of prednisone (P), a brief period of nerve electrical stimulation (ES), and systemic testosterone propionate (TP) on improving functional recovery following an intratemporal facial nerve crush injury. Study Design: Prospective, controlled animal study. Methods: After a right intratemporal facial nerve crush, adult male Sprague-Dawley rats were divided into the following eight treatment groups: 1) no treatment, 2) P only, 3) ES only, 4) ES + P, 5) TP only, 6) TP + P, 7) ES + TP, and 8) ES + TP + P. For each group n = 4-8. Recovery of the eyeblink reflex and vibrissae orientation and movement were assessed. Changes in peak amplitude and latency of evoked response, in response to facial nerve stimulation, was also recorded weekly. Results: Brief ES of the proximal nerve stump most effectively accelerated the initiation of functional recovery. Also, ES or TP treatments enhanced recovery of some functional parameters more than P treatment. When administered alone, none of the three treatments improved recovery of complete facial function. Only the combinatorial treatment of ES + TP, regardless of the presence of P, accelerated complete functional recovery and return of normal motor nerve conduction. Conclusions: Our findings suggest that a combinatorial treatment strategy of using brief ES and TP together promises to be an effective therapeutic intervention for promoting regeneration following facial nerve injury. Administration of P neither augments nor hinders recovery.

Original languageEnglish (US)
Pages (from-to)1523-1530
Number of pages8
JournalLaryngoscope
Volume120
Issue number8
DOIs
StatePublished - Aug 2010
Externally publishedYes

Fingerprint

Nerve Crush
Testosterone Propionate
Facial Nerve
Electric Stimulation
Facial Nerve Injuries
Therapeutics
Vibrissae
Neural Conduction
Prednisone
Reaction Time
Sprague Dawley Rats
Reflex
Regeneration
Prospective Studies

Keywords

  • Electrical stimulation
  • Facial nerve
  • Facial paralysis
  • Nerve injury
  • Nerve regeneration
  • Prednisone
  • Testosterone

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Medicine(all)

Cite this

Sharma, N., Moeller, C. W., Marzo, S. J., Jones, K., & Foecking, E. M. (2010). Combinatorial treatments enhance recovery following facial nerve crush. Laryngoscope, 120(8), 1523-1530. https://doi.org/10.1002/lary.20997

Combinatorial treatments enhance recovery following facial nerve crush. / Sharma, Nijee; Moeller, Carl W.; Marzo, Sam J.; Jones, Kathryn; Foecking, Eileen M.

In: Laryngoscope, Vol. 120, No. 8, 08.2010, p. 1523-1530.

Research output: Contribution to journalArticle

Sharma, N, Moeller, CW, Marzo, SJ, Jones, K & Foecking, EM 2010, 'Combinatorial treatments enhance recovery following facial nerve crush', Laryngoscope, vol. 120, no. 8, pp. 1523-1530. https://doi.org/10.1002/lary.20997
Sharma, Nijee ; Moeller, Carl W. ; Marzo, Sam J. ; Jones, Kathryn ; Foecking, Eileen M. / Combinatorial treatments enhance recovery following facial nerve crush. In: Laryngoscope. 2010 ; Vol. 120, No. 8. pp. 1523-1530.
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