Combined experimental and simulation study of blood clot formation

Zhiliang Xu, Joshua Lioi, Mark Alber, Jian Mu, Xiaomin Liu, Danny Z. Chen, Malgorzata M. Kamocka, Elliot D. Rosen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Scopus citations

Abstract

A multiscale model of blood clot (thrombus) formation is extended by adding a sub-model of the tissue factor (TF) pathway of blood coagulation to provide more biologically relevant description of coagulation process. A combination of experimental approach, image analysis and a multiscale modeling is used for studying role of factor VII and fibrin in limiting growth of a blood clot. The simulations obtained using new extended model, generated a hypothesis that formation of a fiber cap is capable of stopping blood clot growth by blocking release of thrombin, causing activation of platelets, into a blood stream. This was confirmed by comparison with reconstructed three dimensional experimental images of clots formed in mice with normal and limited levels of factor VII.

Original languageEnglish (US)
Title of host publicationTIC-STH'09
Subtitle of host publication2009 IEEE Toronto International Conference - Science and Technology for Humanity
Pages357-362
Number of pages6
DOIs
StatePublished - Dec 1 2009
Event2009 IEEE Toronto International Conference - Science and Technology for Humanity, TIC-STH'09 - Toronto, ON, Canada
Duration: Sep 26 2009Sep 27 2009

Publication series

NameTIC-STH'09: 2009 IEEE Toronto International Conference - Science and Technology for Humanity

Other

Other2009 IEEE Toronto International Conference - Science and Technology for Humanity, TIC-STH'09
CountryCanada
CityToronto, ON
Period9/26/099/27/09

Keywords

  • Blood clot
  • Cellular potts model
  • Image reconstruction and processing
  • Multiscale model
  • Platelet aggregation
  • Stochastic systems
  • Thrombus

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Human Factors and Ergonomics

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  • Cite this

    Xu, Z., Lioi, J., Alber, M., Mu, J., Liu, X., Chen, D. Z., Kamocka, M. M., & Rosen, E. D. (2009). Combined experimental and simulation study of blood clot formation. In TIC-STH'09: 2009 IEEE Toronto International Conference - Science and Technology for Humanity (pp. 357-362). [5444476] (TIC-STH'09: 2009 IEEE Toronto International Conference - Science and Technology for Humanity). https://doi.org/10.1109/TIC-STH.2009.5444476