Combined experimental and simulation study of blood clot formation

Zhiliang Xu, Joshua Lioi, Mark Alber, Jian Mu, Xiaomin Liu, Danny Z. Chen, Malgorzata Kamocka, Elliot Rosen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

A multiscale model of blood clot (thrombus) formation is extended by adding a sub-model of the tissue factor (TF) pathway of blood coagulation to provide more biologically relevant description of coagulation process. A combination of experimental approach, image analysis and a multiscale modeling is used for studying role of factor VII and fibrin in limiting growth of a blood clot. The simulations obtained using new extended model, generated a hypothesis that formation of a fiber cap is capable of stopping blood clot growth by blocking release of thrombin, causing activation of platelets, into a blood stream. This was confirmed by comparison with reconstructed three dimensional experimental images of clots formed in mice with normal and limited levels of factor VII.

Original languageEnglish
Title of host publicationTIC-STH'09: 2009 IEEE Toronto International Conference - Science and Technology for Humanity
Pages357-362
Number of pages6
DOIs
StatePublished - 2009
Event2009 IEEE Toronto International Conference - Science and Technology for Humanity, TIC-STH'09 - Toronto, ON, Canada
Duration: Sep 26 2009Sep 27 2009

Other

Other2009 IEEE Toronto International Conference - Science and Technology for Humanity, TIC-STH'09
CountryCanada
CityToronto, ON
Period9/26/099/27/09

Fingerprint

Blood
simulation
Coagulation
activation
Platelets
Image analysis
Chemical activation
Tissue
Fibers

Keywords

  • Blood clot
  • Cellular potts model
  • Image reconstruction and processing
  • Multiscale model
  • Platelet aggregation
  • Stochastic systems
  • Thrombus

ASJC Scopus subject areas

  • Computational Theory and Mathematics
  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Human Factors and Ergonomics

Cite this

Xu, Z., Lioi, J., Alber, M., Mu, J., Liu, X., Chen, D. Z., ... Rosen, E. (2009). Combined experimental and simulation study of blood clot formation. In TIC-STH'09: 2009 IEEE Toronto International Conference - Science and Technology for Humanity (pp. 357-362). [5444476] https://doi.org/10.1109/TIC-STH.2009.5444476

Combined experimental and simulation study of blood clot formation. / Xu, Zhiliang; Lioi, Joshua; Alber, Mark; Mu, Jian; Liu, Xiaomin; Chen, Danny Z.; Kamocka, Malgorzata; Rosen, Elliot.

TIC-STH'09: 2009 IEEE Toronto International Conference - Science and Technology for Humanity. 2009. p. 357-362 5444476.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Xu, Z, Lioi, J, Alber, M, Mu, J, Liu, X, Chen, DZ, Kamocka, M & Rosen, E 2009, Combined experimental and simulation study of blood clot formation. in TIC-STH'09: 2009 IEEE Toronto International Conference - Science and Technology for Humanity., 5444476, pp. 357-362, 2009 IEEE Toronto International Conference - Science and Technology for Humanity, TIC-STH'09, Toronto, ON, Canada, 9/26/09. https://doi.org/10.1109/TIC-STH.2009.5444476
Xu Z, Lioi J, Alber M, Mu J, Liu X, Chen DZ et al. Combined experimental and simulation study of blood clot formation. In TIC-STH'09: 2009 IEEE Toronto International Conference - Science and Technology for Humanity. 2009. p. 357-362. 5444476 https://doi.org/10.1109/TIC-STH.2009.5444476
Xu, Zhiliang ; Lioi, Joshua ; Alber, Mark ; Mu, Jian ; Liu, Xiaomin ; Chen, Danny Z. ; Kamocka, Malgorzata ; Rosen, Elliot. / Combined experimental and simulation study of blood clot formation. TIC-STH'09: 2009 IEEE Toronto International Conference - Science and Technology for Humanity. 2009. pp. 357-362
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