Combined penetrating keratoplasty and trabeculectomy with mitomycin C

Darrell WuDunn, Eduardo Alfonso, Paul F. Palmberg

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective: To evaluate corneal graft survival and intraocular pressure control in eyes that have undergone combined penetrating keratoplasty and trabeculectomy with mitomycin C (MMC). Design: Retrospective noncomparative case series. Intervention: Penetrating keratoplasty combined with trabeculectomy with MMC and other surgical procedures. Participants: Twenty- four eyes of 22 patients undergoing combined penetrating keratoplasty and trabeculectomy with mitomycin C. Main Outcome Measures: Corneal graft clarity and intraocular pressure control. Results: The cumulative probability of corneal graft survival was 85% at 1 year and 60% at 2 years. The cumulative probability of adequate pressure control was 67% at 3 months, 55% at 12 months, and 50% at 24 months. The incidence of bleb failure was higher in cases involving additional concomitant procedures, such as anterior vitrectomy, lens implantation or exchange, and drainage tube implantation. Conclusions: Combined penetrating keratoplasty and trabeculectomy with mitomycin C is associated with good corneal graft survival but also a risk of early failure of intraocular pressure control. Other concomitant procedures during the combined penetrating keratoplasty/trabeculectomy may increase the risk of early bleb failure.

Original languageEnglish
Pages (from-to)396-400
Number of pages5
JournalOphthalmology
Volume106
Issue number2
StatePublished - Feb 1 1999

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Penetrating Keratoplasty
Trabeculectomy
Mitomycin
Graft Survival
Intraocular Pressure
Blister
Vitrectomy
Lenses
Drainage
Outcome Assessment (Health Care)
Transplants
Pressure
Incidence

ASJC Scopus subject areas

  • Ophthalmology

Cite this

WuDunn, D., Alfonso, E., & Palmberg, P. F. (1999). Combined penetrating keratoplasty and trabeculectomy with mitomycin C. Ophthalmology, 106(2), 396-400.

Combined penetrating keratoplasty and trabeculectomy with mitomycin C. / WuDunn, Darrell; Alfonso, Eduardo; Palmberg, Paul F.

In: Ophthalmology, Vol. 106, No. 2, 01.02.1999, p. 396-400.

Research output: Contribution to journalArticle

WuDunn, D, Alfonso, E & Palmberg, PF 1999, 'Combined penetrating keratoplasty and trabeculectomy with mitomycin C', Ophthalmology, vol. 106, no. 2, pp. 396-400.
WuDunn D, Alfonso E, Palmberg PF. Combined penetrating keratoplasty and trabeculectomy with mitomycin C. Ophthalmology. 1999 Feb 1;106(2):396-400.
WuDunn, Darrell ; Alfonso, Eduardo ; Palmberg, Paul F. / Combined penetrating keratoplasty and trabeculectomy with mitomycin C. In: Ophthalmology. 1999 ; Vol. 106, No. 2. pp. 396-400.
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