Combined use of growth hormone and gonadotropin-releasing hormone analogues in precocious puberty: Theoretic and practical considerations

Emily C. Walvoord, Ora Hirsch Pescovitz

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

The rationale underlying the use of gonadotropin-releasing hormone analogues (GnRHa) to treat patients with central precocious puberty is reviewed. GnRHa are now considered the treatment of choice for patients with central precocious puberty, but the adult heights that these patients attain often fall short of what would be expected according to their genetic potential. This has led to investigations of whether adding growth hormone to GnRHa therapy can improve adult height. The results of recent combination trials are presented and analyzed.

Original languageEnglish (US)
Pages (from-to)1010-1014
Number of pages5
JournalPediatrics
Volume104
Issue number4 II
StatePublished - Oct 1 1999

Keywords

  • Combination therapy
  • Gonadotropin-releasing hormone
  • Growth hormone
  • Precocious puberty

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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