Combining prediction, computation and experiment for the characterization of protein disorder

Clay Bracken, Lilia M. Iakoucheva, Pedro R. Romero, A. Keith Dunker

Research output: Contribution to journalReview article

104 Scopus citations

Abstract

Several computational and experimental methods exist for identifying disordered residues within proteins. Computational algorithms can now identify these disordered sequences and predict their occurrence within genomes with relatively high accuracy. Recent advances in NMR and mass spectroscopy permit faster and more detailed studies of disordered states at atomic resolutions. Combining prediction, computation and experimentation is proposed to accelerate and enhance the characterization of intrinsically disordered protein.

Original languageEnglish (US)
Pages (from-to)570-576
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume14
Issue number5
DOIs
StatePublished - Oct 1 2004

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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