Common genetic polymorphisms of adenosine A2A receptor do not influence response to regadenoson

Mark Berlacher, Ronald Mastouri, Santosh Philips, Todd C. Skaar, Rolf P. Kreutz

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Aim: Hemodynamic response to regadenoson varies greatly, and underlying mechanisms for variability are poorly understood. We hypothesized that five common variants of adenosine A2A receptor (ADORA2A) are associated with altered response to regadenoson. Methods: Consecutive subjects (n = 357) undergoing resting regadenoson nuclear stress imaging were enrolled. Genotyping was performed using Taqman-based assays for rs5751862, rs2298383, rs3761422, rs2267076 and rs5751876. Results: There was no significant difference in heart rate or blood pressure between different genotypes following regadenoson administration. There was also no significant difference in myocardial ischemia detected by nuclear perfusion imaging as defined by summed difference score, or in self-reported side effects among the genotypes tested. Conclusion: The common A2A variants studied are not associated with variability in hemodynamic response to regadenoson or variability in detection of ischemia with nuclear perfusion stress imaging.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalPharmacogenomics
Volume18
Issue number6
DOIs
StatePublished - Apr 2017

Keywords

  • adenosine
  • genetic
  • myocardial perfusion imaging
  • regadenoson

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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