Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia

Susan Storey, Tamryn Fowler Gray, Ashley Leak Bryant

Research output: Contribution to journalReview article

Abstract

Purpose of Review: The purpose of this study is to describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults. Recent Findings: AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes, and QOL. Summary: As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment-related outcomes. Prospective, longitudinal, and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes, and QOL.

Original languageEnglish (US)
Pages (from-to)247-254
Number of pages8
JournalCurrent Geriatrics Reports
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2017

Fingerprint

Acute Myeloid Leukemia
Comorbidity
Quality of Life
Hematologic Diseases
Pathology
Mutation
Therapeutics
Population

Keywords

  • Acute myeloid leukemia
  • Comorbidities
  • Older adults
  • Patient-reported outcomes
  • Physical function
  • Quality of life
  • Symptoms

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia. / Storey, Susan; Gray, Tamryn Fowler; Bryant, Ashley Leak.

In: Current Geriatrics Reports, Vol. 6, No. 4, 01.12.2017, p. 247-254.

Research output: Contribution to journalReview article

Storey, Susan ; Gray, Tamryn Fowler ; Bryant, Ashley Leak. / Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia. In: Current Geriatrics Reports. 2017 ; Vol. 6, No. 4. pp. 247-254.
@article{7913a5dac97744f38a07e284d5591542,
title = "Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia",
abstract = "Purpose of Review: The purpose of this study is to describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults. Recent Findings: AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes, and QOL. Summary: As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment-related outcomes. Prospective, longitudinal, and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes, and QOL.",
keywords = "Acute myeloid leukemia, Comorbidities, Older adults, Patient-reported outcomes, Physical function, Quality of life, Symptoms",
author = "Susan Storey and Gray, {Tamryn Fowler} and Bryant, {Ashley Leak}",
year = "2017",
month = "12",
day = "1",
doi = "10.1007/s13670-017-0227-8",
language = "English (US)",
volume = "6",
pages = "247--254",
journal = "Current Geriatrics Reports",
issn = "1672-6340",
publisher = "Springer Science + Business Media",
number = "4",

}

TY - JOUR

T1 - Comorbidity, Physical Function, and Quality of Life in Older Adults with Acute Myeloid Leukemia

AU - Storey, Susan

AU - Gray, Tamryn Fowler

AU - Bryant, Ashley Leak

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Purpose of Review: The purpose of this study is to describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults. Recent Findings: AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes, and QOL. Summary: As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment-related outcomes. Prospective, longitudinal, and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes, and QOL.

AB - Purpose of Review: The purpose of this study is to describe the pathology, impact of comorbidities, functional limitations, symptoms, and quality of life (QOL) related to treatment of acute myeloid leukemia (AML) in older adults. Recent Findings: AML is a rare aggressive hematologic disease that occurs most often in older adults. The prognosis for older patients with AML is markedly worse due to genetic mutations and patient characteristics such as comorbidities and functional limitations. Patient characteristics may influence treatment decisions, as well as impact symptoms, functional ability, health-related outcomes, and QOL. Summary: As the population continues to age, the number of people diagnosed with AML is expected to increase. Better management of comorbidities is imperative to improving QOL and other treatment-related outcomes. Prospective, longitudinal, and multi-site studies are warranted to further understand the interaction between these characteristics on symptoms, outcomes, and QOL.

KW - Acute myeloid leukemia

KW - Comorbidities

KW - Older adults

KW - Patient-reported outcomes

KW - Physical function

KW - Quality of life

KW - Symptoms

UR - http://www.scopus.com/inward/record.url?scp=85037609523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037609523&partnerID=8YFLogxK

U2 - 10.1007/s13670-017-0227-8

DO - 10.1007/s13670-017-0227-8

M3 - Review article

AN - SCOPUS:85037609523

VL - 6

SP - 247

EP - 254

JO - Current Geriatrics Reports

JF - Current Geriatrics Reports

SN - 1672-6340

IS - 4

ER -