Comparative analysis of epidermal growth factor receptor gene expression and protein product in benign, premalignant, and malignant prostate tissue

L. N. Turkeri, W. A. Sakr, S. M. Wykes, David Grignon, J. E. Pontes, J. A. Macoska

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

In order to more clearly define the status of epidermal growth factor receptor (EGFR) in prostate cancer, expression of EGFR transcript and protein was analyzed in paired samples of benign and malignant tissues from 30 radical prostatectomy specimens. Prostate tumors and high grade prostatic intraepithelial neoplasias (PINs) expressed significantly less EGFR protein than benign tissues or low grade PINs (P <0.001). Expression of EGFR mRNA was analyzed in a subset of the same samples, and was higher in more prostate tumors than benign specimens (P <0.05). However, differences in mean mRNA expression between malignant and benign tissues were not significant. EGFR mRNA was expressed at moderate or low levels in equivalent numbers of PIN lesions. These results suggest that, although EGFR mRNA expression is somewhat elevated in prostate tumors, EGFR protein expression may be down- regulated in the same malignant tissues. Furthermore, our data demonstrate phenotypic similarity between prostate tumors and high grade PIN at the level of EGFR protein expression.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalProstate
Volume25
Issue number4
DOIs
StatePublished - 1994
Externally publishedYes

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erbB-1 Genes
Epidermal Growth Factor Receptor
Prostate
Prostatic Intraepithelial Neoplasia
Gene Expression
Proteins
Messenger RNA
Neoplasms
Prostatectomy
Prostatic Neoplasms

Keywords

  • histologic control
  • PIN tumorigenesis
  • prostatectomy
  • tissue architecture

ASJC Scopus subject areas

  • Urology

Cite this

Comparative analysis of epidermal growth factor receptor gene expression and protein product in benign, premalignant, and malignant prostate tissue. / Turkeri, L. N.; Sakr, W. A.; Wykes, S. M.; Grignon, David; Pontes, J. E.; Macoska, J. A.

In: Prostate, Vol. 25, No. 4, 1994, p. 199-205.

Research output: Contribution to journalArticle

Turkeri, L. N. ; Sakr, W. A. ; Wykes, S. M. ; Grignon, David ; Pontes, J. E. ; Macoska, J. A. / Comparative analysis of epidermal growth factor receptor gene expression and protein product in benign, premalignant, and malignant prostate tissue. In: Prostate. 1994 ; Vol. 25, No. 4. pp. 199-205.
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