Comparative analysis of the effects of dorzolamide and latanoprost on ocular hemodynamics in normal tension glaucoma patients

Alon Harris, R. Migliardi, E. Rechtman, C. N. Cole, A. B. Yee, H. J. Garzozi

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

PURPOSE. To compare the effects of latanoprost (Xalatan®) and dorzolamide (Trusopt®) on ocular hemodynamics in normal-tension glaucoma patients. METHODS. A randomized, single-masked, parallel design study was conducted. After a 4 - week washout period, 20 normal tension glaucoma patients, recruited from a single university-based ophthalmology clinic, received either latanoprost once daily or dorzolamide 3 times daily for 4 weeks. The subjects were examined at baseline and post-treatment. Outcome measures included heart rate (HR), blood pressure (BP), logMar visual acuity (Vii)(VA), contrast sensitivity (CS), intraocular pressure (lOP)(IOP), color Doppler imaging (CDI), and fluorescein angiography with the Rodenstock scanning laser ophthalmoscope (SLO). CDI measurements of the retrobulbar vessels included peak systolic velocity, end diastolic velocity, and the calculated resistance index. Arterio-venous passage time (AVP) in the superior and inferior temporal retina was calculated from the SLO angiograms. RESULTS. Neither dorzolamide nor latanoprost had any statistically significantly effect on HR or BP. Both drugs significantly lowered IOP without altering calculated ocular perfusion pressure (p<0.05). There was no statistically significant difference in any CDI measurement. Dorzolamide significantly decreased AVP time in the superior retina (p=0.011), while latanoprost did not (p=0.62). CONCLUSIONS. Dorzolamide, unlike latanoprost, significantly reduced AVP times in the superior temporal retina in normal tension glaucoma (NTG) patients.

Original languageEnglish
Pages (from-to)24-31
Number of pages8
JournalEuropean Journal of Ophthalmology
Volume13
Issue number1
StatePublished - Jan 2003

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latanoprost
dorzolamide
Low Tension Glaucoma
Hemodynamics
Ophthalmoscopes
Retina
Color
Intraocular Pressure
Lasers
Heart Rate
Blood Pressure
Contrast Sensitivity
Fluorescein Angiography
Ophthalmology
Visual Acuity
Angiography

Keywords

  • AVP time
  • Dorzolamide
  • Glaucoma
  • Hemodynamics
  • Latanoprost

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Comparative analysis of the effects of dorzolamide and latanoprost on ocular hemodynamics in normal tension glaucoma patients. / Harris, Alon; Migliardi, R.; Rechtman, E.; Cole, C. N.; Yee, A. B.; Garzozi, H. J.

In: European Journal of Ophthalmology, Vol. 13, No. 1, 01.2003, p. 24-31.

Research output: Contribution to journalArticle

Harris, Alon ; Migliardi, R. ; Rechtman, E. ; Cole, C. N. ; Yee, A. B. ; Garzozi, H. J. / Comparative analysis of the effects of dorzolamide and latanoprost on ocular hemodynamics in normal tension glaucoma patients. In: European Journal of Ophthalmology. 2003 ; Vol. 13, No. 1. pp. 24-31.
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N2 - PURPOSE. To compare the effects of latanoprost (Xalatan®) and dorzolamide (Trusopt®) on ocular hemodynamics in normal-tension glaucoma patients. METHODS. A randomized, single-masked, parallel design study was conducted. After a 4 - week washout period, 20 normal tension glaucoma patients, recruited from a single university-based ophthalmology clinic, received either latanoprost once daily or dorzolamide 3 times daily for 4 weeks. The subjects were examined at baseline and post-treatment. Outcome measures included heart rate (HR), blood pressure (BP), logMar visual acuity (Vii)(VA), contrast sensitivity (CS), intraocular pressure (lOP)(IOP), color Doppler imaging (CDI), and fluorescein angiography with the Rodenstock scanning laser ophthalmoscope (SLO). CDI measurements of the retrobulbar vessels included peak systolic velocity, end diastolic velocity, and the calculated resistance index. Arterio-venous passage time (AVP) in the superior and inferior temporal retina was calculated from the SLO angiograms. RESULTS. Neither dorzolamide nor latanoprost had any statistically significantly effect on HR or BP. Both drugs significantly lowered IOP without altering calculated ocular perfusion pressure (p<0.05). There was no statistically significant difference in any CDI measurement. Dorzolamide significantly decreased AVP time in the superior retina (p=0.011), while latanoprost did not (p=0.62). CONCLUSIONS. Dorzolamide, unlike latanoprost, significantly reduced AVP times in the superior temporal retina in normal tension glaucoma (NTG) patients.

AB - PURPOSE. To compare the effects of latanoprost (Xalatan®) and dorzolamide (Trusopt®) on ocular hemodynamics in normal-tension glaucoma patients. METHODS. A randomized, single-masked, parallel design study was conducted. After a 4 - week washout period, 20 normal tension glaucoma patients, recruited from a single university-based ophthalmology clinic, received either latanoprost once daily or dorzolamide 3 times daily for 4 weeks. The subjects were examined at baseline and post-treatment. Outcome measures included heart rate (HR), blood pressure (BP), logMar visual acuity (Vii)(VA), contrast sensitivity (CS), intraocular pressure (lOP)(IOP), color Doppler imaging (CDI), and fluorescein angiography with the Rodenstock scanning laser ophthalmoscope (SLO). CDI measurements of the retrobulbar vessels included peak systolic velocity, end diastolic velocity, and the calculated resistance index. Arterio-venous passage time (AVP) in the superior and inferior temporal retina was calculated from the SLO angiograms. RESULTS. Neither dorzolamide nor latanoprost had any statistically significantly effect on HR or BP. Both drugs significantly lowered IOP without altering calculated ocular perfusion pressure (p<0.05). There was no statistically significant difference in any CDI measurement. Dorzolamide significantly decreased AVP time in the superior retina (p=0.011), while latanoprost did not (p=0.62). CONCLUSIONS. Dorzolamide, unlike latanoprost, significantly reduced AVP times in the superior temporal retina in normal tension glaucoma (NTG) patients.

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