Comparative antihyperlipidemic effects of Simvastatin and Lovastatin

Yun Man Li, Zhi Gang Lei, Gui Cheng Yang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

AIM: The purpose is to compare antihyperlipidemic action of Simvastatin and Lovastatin. METHODS: Two hyperlipidemic modegl were induced by fedding a high lipidic diet and intraperitoneal injection Triton WR 1339 in rats. RESULTS: Simvastatin could significantly reduce serum cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) concentrations and TC/HDL-C ratio, and increase the high density lipoprotein-cholesterol (HDL-C) concentration in rats fed a high hipidic diet. In this model, it also lowered liver TC and TG levels. In addition, we found that serum TC and liver TC in Triton induced hyperlipemia rats were reduced by simvastatin. Antihyperlipidemic action of Lovastatin is lower than that of simvastatin. CONCLUSION: These antihyperlipidemic effects of simvastatin are more potent than those of lovastatin (P< 0.05, P<0.01).

Original languageEnglish (US)
Pages (from-to)448-450
Number of pages3
JournalJournal of China Pharmaceutical University
Volume33
Issue number5
StatePublished - Oct 1 2002

Keywords

  • Antihyperlipidemic action
  • Cholesterol
  • Lovastatin
  • Simvastatin
  • Triglyceride

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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