AIM: The purpose is to compare antihyperlipidemic action of Simvastatin and Lovastatin. METHODS: Two hyperlipidemic modegl were induced by fedding a high lipidic diet and intraperitoneal injection Triton WR 1339 in rats. RESULTS: Simvastatin could significantly reduce serum cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) concentrations and TC/HDL-C ratio, and increase the high density lipoprotein-cholesterol (HDL-C) concentration in rats fed a high hipidic diet. In this model, it also lowered liver TC and TG levels. In addition, we found that serum TC and liver TC in Triton induced hyperlipemia rats were reduced by simvastatin. Antihyperlipidemic action of Lovastatin is lower than that of simvastatin. CONCLUSION: These antihyperlipidemic effects of simvastatin are more potent than those of lovastatin (P< 0.05, P<0.01).
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of China Pharmaceutical University|
|State||Published - Oct 1 2002|
- Antihyperlipidemic action
ASJC Scopus subject areas
- Pharmaceutical Science