Comparative effects of tobramycin and gentamicin on glomerular ultrastructure

F. C. Luft, A. P. Evan

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Abstract

To examine and compare the effects of tobramycin and gentamicin on glomerular endothelium, these drugs were given to rats at dosages of 80, 40, or 4 mg/kg day for 10 days, when detailed, quantitative scanning electron microscopic studies of glomerular architecture were performed. Gentamicin caused significant dose-related decreases in endogenous creatinine clearance, but tobramycin did not. Gentamicin administration resulted in a decrease in the diameter and density of endothelial fenestrae at all dosages tested. The changes were dose-dependent and accounted for a decrease in filtration area ranging from 75% at 4 mg/kg per day to 36% at 80 mg/kg per day. Tobramycin administration caused only minor alterations, even at the high dosages, which did not significantly reduce filtration area. Thus, the difference in effect on glomerular filtration rate caused by gentamicin and tobramycin corresponds closely to differences in their effects on glomerular ultrastructure.

Original languageEnglish (US)
Pages (from-to)910-914
Number of pages5
JournalJournal of Infectious Diseases
Volume142
Issue number6
DOIs
StatePublished - Jan 1 1980

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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