Comparative immunocytochemical characterization of neurofibrillary tangles in experimental maytansine and aluminum encephalopathies

Bernardino Ghetti, Pierluigi Gambetti

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The neurofibrillary tangles induced by maytansine and aluminum are stained by the peroxidase-anti-peroxidase method, using antibodies raised against the 68, 150 and 200 kdaltons polypeptide subunits of normal neurofilaments. The immunoreaction with each of the 3 antisera occurs regardless of the location of the neurofilament accumulation, whether in perikarya, dendrites or axons. It is very likely that the filaments of the neurofibrillary tangles induced by both aluminum and maytansine contain all the 3 neurofilament subunits.

Original languageEnglish
Pages (from-to)388-393
Number of pages6
JournalBrain Research
Volume276
Issue number2
DOIs
StatePublished - Oct 16 1983

Fingerprint

Maytansine
Neurofibrillary Tangles
Intermediate Filaments
Brain Diseases
Aluminum
Peroxidase
Dendrites
Axons
Immune Sera
Peptides
Antibodies

Keywords

  • aluminum
  • antibodies
  • maytansine
  • neurofibrillary tangles
  • neurofilament
  • polypeptide subunits

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Comparative immunocytochemical characterization of neurofibrillary tangles in experimental maytansine and aluminum encephalopathies. / Ghetti, Bernardino; Gambetti, Pierluigi.

In: Brain Research, Vol. 276, No. 2, 16.10.1983, p. 388-393.

Research output: Contribution to journalArticle

@article{6caf11ce46dc420eb398639e8cacc7e0,
title = "Comparative immunocytochemical characterization of neurofibrillary tangles in experimental maytansine and aluminum encephalopathies",
abstract = "The neurofibrillary tangles induced by maytansine and aluminum are stained by the peroxidase-anti-peroxidase method, using antibodies raised against the 68, 150 and 200 kdaltons polypeptide subunits of normal neurofilaments. The immunoreaction with each of the 3 antisera occurs regardless of the location of the neurofilament accumulation, whether in perikarya, dendrites or axons. It is very likely that the filaments of the neurofibrillary tangles induced by both aluminum and maytansine contain all the 3 neurofilament subunits.",
keywords = "aluminum, antibodies, maytansine, neurofibrillary tangles, neurofilament, polypeptide subunits",
author = "Bernardino Ghetti and Pierluigi Gambetti",
year = "1983",
month = "10",
day = "16",
doi = "10.1016/0006-8993(83)90754-0",
language = "English",
volume = "276",
pages = "388--393",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Comparative immunocytochemical characterization of neurofibrillary tangles in experimental maytansine and aluminum encephalopathies

AU - Ghetti, Bernardino

AU - Gambetti, Pierluigi

PY - 1983/10/16

Y1 - 1983/10/16

N2 - The neurofibrillary tangles induced by maytansine and aluminum are stained by the peroxidase-anti-peroxidase method, using antibodies raised against the 68, 150 and 200 kdaltons polypeptide subunits of normal neurofilaments. The immunoreaction with each of the 3 antisera occurs regardless of the location of the neurofilament accumulation, whether in perikarya, dendrites or axons. It is very likely that the filaments of the neurofibrillary tangles induced by both aluminum and maytansine contain all the 3 neurofilament subunits.

AB - The neurofibrillary tangles induced by maytansine and aluminum are stained by the peroxidase-anti-peroxidase method, using antibodies raised against the 68, 150 and 200 kdaltons polypeptide subunits of normal neurofilaments. The immunoreaction with each of the 3 antisera occurs regardless of the location of the neurofilament accumulation, whether in perikarya, dendrites or axons. It is very likely that the filaments of the neurofibrillary tangles induced by both aluminum and maytansine contain all the 3 neurofilament subunits.

KW - aluminum

KW - antibodies

KW - maytansine

KW - neurofibrillary tangles

KW - neurofilament

KW - polypeptide subunits

UR - http://www.scopus.com/inward/record.url?scp=0020601572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020601572&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(83)90754-0

DO - 10.1016/0006-8993(83)90754-0

M3 - Article

VL - 276

SP - 388

EP - 393

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -