Comparative physiology of the piscine natriuretic peptide system

Keven R. Johnson, Kenneth Olson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The natriuretic peptide (NP) family is a seemingly ubiquitous sodium and volume reducing endocrine system of predominantly cardiac origin. Members of the NP system include ANP, BNP, CNP, VNP, their guanylate cyclase (GC)-linked receptors (NPR-A and NPR-B), and clearance receptor (NPR-C). Through the activation of their membrane-bound GC receptors, these small peptides modulate cellular functions that affect both salt and water balance. The elucidation of piscine NP sequences, structure, and functions has steadily advanced over the past 15 years spearheaded by research from Dr. Yoshio Takei's laboratory. The development of these homologous NPs has led to extensive research into both the evolutionary and physiological significance of NPs in fishes. One outcome has been the development of two seemingly disparate hypotheses of NP function; a role in salt excretion, the osmoregulatory hypothesis, versus a role in protecting the heart, the cardioprotective hypotheses. In the osmoregulatory hypothesis NPs are released in response to elevated ambient salinity and inhibit drinking and intestinal uptake of salt, thereby effectively reducing plasma sodium levels. In contrast, the cardioprotective theory depicts NPs acting to prevent debilitating cardiodilation from an excess of either venous or arterial pressure through vasodilation and a reduction of blood volume. These seemingly distinct hypotheses may be elements of a more general regulatory system and certainly require further investigation. Undoubtedly their resolution will not only give us a better perspective of the evolutionary basis of the NP system but will provide us with a greater appreciation of salt and water homeostasis in vertebrates.

Original languageEnglish
Pages (from-to)21-26
Number of pages6
JournalGeneral and Comparative Endocrinology
Volume157
Issue number1
DOIs
StatePublished - May 15 2008

Fingerprint

Comparative Physiology
natriuretic peptides
Natriuretic Peptides
physiology
Salts
salts
guanylate cyclase
Guanylate Cyclase
receptors
Sodium
sodium
endocrine system
Endocrine System
Venous Pressure
Peptide Receptors
blood volume
vasodilation
Water
Salinity
Atrial Natriuretic Factor

Keywords

  • Cardioprotection
  • Osmoregulation
  • Volume regulation

ASJC Scopus subject areas

  • Endocrinology

Cite this

Comparative physiology of the piscine natriuretic peptide system. / Johnson, Keven R.; Olson, Kenneth.

In: General and Comparative Endocrinology, Vol. 157, No. 1, 15.05.2008, p. 21-26.

Research output: Contribution to journalArticle

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