Comparative respiratory system mechanics in rodents

R. F M Gomes, X. Shen, R. Ramchandani, Robert Tepper, J. H T Bates

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Because of the wide utilization of rodents as animal models in respiratory research and the limited data on measurements of respiratory input impedance (Zrs) in small animals, we measured Zrs between 0.25 and 9.125 Hz at different levels (0-7 hPa) of positive end-expiratory pressure (PEEP) in mice, rats, guinea pigs, and rabbits using a computer-controlled small-animal ventilator (Schuessler TF and Bates JHT, IEEE Trans Biomed Eng 42: 860-866, 1995). Zrs was fitted with a model, including a Newtonian resistance (R) and inertance in series with a constant-phase tissue compartment characterized by tissue damping (Gti) and elastance (Hti) parameters. Inertance was negligible in all cases. R, Gti, and Hti were normalized to body weight, yielding normalized R, Gti, and Hti (NHti), respectively. Normalized R tended to decrease slightly with PEEP and increased with animal size. Normalized Gti had a minimal dependence on PEEP. NHti decreased with increasing PEEP, reaching a minimum at ∼5 hPa in all species except mice. NHti was also higher in mice and rabbits compared with guinea pigs and rats at low PEEPs, which we conclude is probably due to a relatively smaller air space volume in mice and rabbits. Our data also suggest that smaller rodents have proportionately wider airways than do larger animals. We conclude that a detailed, comparative study of respiratory system mechanics shows some evidence of structural differences among the lungs of various species but that, in general, rodent lungs obey scaling laws similar to those described in other species.

Original languageEnglish
Pages (from-to)908-916
Number of pages9
JournalJournal of Applied Physiology
Volume89
Issue number3
StatePublished - 2000

Fingerprint

Respiratory Mechanics
Positive-Pressure Respiration
Respiratory System
Rodentia
Rabbits
Guinea Pigs
Lung
Mechanical Ventilators
Electric Impedance
Animal Models
Air
Body Weight
Research

Keywords

  • Comparative physiology
  • Forced oscillations
  • Respiratory system impedance
  • Small rodents

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Gomes, R. F. M., Shen, X., Ramchandani, R., Tepper, R., & Bates, J. H. T. (2000). Comparative respiratory system mechanics in rodents. Journal of Applied Physiology, 89(3), 908-916.

Comparative respiratory system mechanics in rodents. / Gomes, R. F M; Shen, X.; Ramchandani, R.; Tepper, Robert; Bates, J. H T.

In: Journal of Applied Physiology, Vol. 89, No. 3, 2000, p. 908-916.

Research output: Contribution to journalArticle

Gomes, RFM, Shen, X, Ramchandani, R, Tepper, R & Bates, JHT 2000, 'Comparative respiratory system mechanics in rodents', Journal of Applied Physiology, vol. 89, no. 3, pp. 908-916.
Gomes RFM, Shen X, Ramchandani R, Tepper R, Bates JHT. Comparative respiratory system mechanics in rodents. Journal of Applied Physiology. 2000;89(3):908-916.
Gomes, R. F M ; Shen, X. ; Ramchandani, R. ; Tepper, Robert ; Bates, J. H T. / Comparative respiratory system mechanics in rodents. In: Journal of Applied Physiology. 2000 ; Vol. 89, No. 3. pp. 908-916.
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