Comparative studies of prostate cancers among United States, Chinese, and Japanese patients

characterization of histopathology, tumor angiogenesis, neuroendocrine factors, and p53 protein accumulations

Haiyen E. Zhau, Lian Sheng Zhao, Leland W K Chung, Bao Qi Chen, Patricia Troncoso, Chinghai Kao, Munekado Kojima, W. Fraser Symmans, Ninjia Zheng, Judy L. Palmer, Judd W. Moul, Rodney Davis, Ming Fu Ye, Lian Sheng Xiao, M. Craig Hall

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Although interracial differences of prostate cancer progression are well recognized, their underlying molecular and cellular mechanisms remain obscure. We compared the histopathologic, immunohistochemical, and molecular characteristics of unselected prostate cancer tissues obtained from U.S., Chinese, and Japanese men. Histopathologic analyses indicated that 74.4% of the prostate cancers in Chinese men were poorly differentiated, compared with 28.6% and 32.8% of the prostate cancers in U.S. and Japanese men, respectively. These differences cannot be attributed to patient age, clinical stage of disease, or methods of tissue sampling. The high proportion of poorly differentiated prostate cancer tissues in the Chinese group was not related to the patients' access to medical service or to geographic background within China. Significantly higher levels of tumor angiogenesis (2- to 4-fold), serotonin (2- to 20-fold), and bombesin (7- to 16-fold), but not chromogranin A, were found in the tissue specimens obtained from Chinese prostate cancer patients compared with those from U.S. and Japanese patients. We also observed marked interracial differences in p53 protein accumulation. The protein was present in 90.2% of Chinese specimens; 17.4% of specimens from U.S. whites; 7.1% of specimens from Japanese men; and 3.7% of specimens from U.S. blacks. Results from multivariate logistic regression analysis demonstrated that p53 protein accumulation, angiogenesis, and serotonin expression in the normal stroma area correlate independently with Chinese versus non-Chinese patient populations.

Original languageEnglish (US)
Pages (from-to)51-63
Number of pages13
JournalUrologic Oncology: Seminars and Original Investigations
Volume1
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

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Neuroendocrine Tumors
Angiogenesis Inducing Agents
Prostatic Neoplasms
Proteins
Serotonin
Chromogranin A
Bombesin
China
Logistic Models
Regression Analysis
Population
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Comparative studies of prostate cancers among United States, Chinese, and Japanese patients : characterization of histopathology, tumor angiogenesis, neuroendocrine factors, and p53 protein accumulations. / Zhau, Haiyen E.; Zhao, Lian Sheng; Chung, Leland W K; Chen, Bao Qi; Troncoso, Patricia; Kao, Chinghai; Kojima, Munekado; Fraser Symmans, W.; Zheng, Ninjia; Palmer, Judy L.; Moul, Judd W.; Davis, Rodney; Ye, Ming Fu; Xiao, Lian Sheng; Craig Hall, M.

In: Urologic Oncology: Seminars and Original Investigations, Vol. 1, No. 2, 1995, p. 51-63.

Research output: Contribution to journalArticle

Zhau, Haiyen E. ; Zhao, Lian Sheng ; Chung, Leland W K ; Chen, Bao Qi ; Troncoso, Patricia ; Kao, Chinghai ; Kojima, Munekado ; Fraser Symmans, W. ; Zheng, Ninjia ; Palmer, Judy L. ; Moul, Judd W. ; Davis, Rodney ; Ye, Ming Fu ; Xiao, Lian Sheng ; Craig Hall, M. / Comparative studies of prostate cancers among United States, Chinese, and Japanese patients : characterization of histopathology, tumor angiogenesis, neuroendocrine factors, and p53 protein accumulations. In: Urologic Oncology: Seminars and Original Investigations. 1995 ; Vol. 1, No. 2. pp. 51-63.
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abstract = "Although interracial differences of prostate cancer progression are well recognized, their underlying molecular and cellular mechanisms remain obscure. We compared the histopathologic, immunohistochemical, and molecular characteristics of unselected prostate cancer tissues obtained from U.S., Chinese, and Japanese men. Histopathologic analyses indicated that 74.4{\%} of the prostate cancers in Chinese men were poorly differentiated, compared with 28.6{\%} and 32.8{\%} of the prostate cancers in U.S. and Japanese men, respectively. These differences cannot be attributed to patient age, clinical stage of disease, or methods of tissue sampling. The high proportion of poorly differentiated prostate cancer tissues in the Chinese group was not related to the patients' access to medical service or to geographic background within China. Significantly higher levels of tumor angiogenesis (2- to 4-fold), serotonin (2- to 20-fold), and bombesin (7- to 16-fold), but not chromogranin A, were found in the tissue specimens obtained from Chinese prostate cancer patients compared with those from U.S. and Japanese patients. We also observed marked interracial differences in p53 protein accumulation. The protein was present in 90.2{\%} of Chinese specimens; 17.4{\%} of specimens from U.S. whites; 7.1{\%} of specimens from Japanese men; and 3.7{\%} of specimens from U.S. blacks. Results from multivariate logistic regression analysis demonstrated that p53 protein accumulation, angiogenesis, and serotonin expression in the normal stroma area correlate independently with Chinese versus non-Chinese patient populations.",
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T1 - Comparative studies of prostate cancers among United States, Chinese, and Japanese patients

T2 - characterization of histopathology, tumor angiogenesis, neuroendocrine factors, and p53 protein accumulations

AU - Zhau, Haiyen E.

AU - Zhao, Lian Sheng

AU - Chung, Leland W K

AU - Chen, Bao Qi

AU - Troncoso, Patricia

AU - Kao, Chinghai

AU - Kojima, Munekado

AU - Fraser Symmans, W.

AU - Zheng, Ninjia

AU - Palmer, Judy L.

AU - Moul, Judd W.

AU - Davis, Rodney

AU - Ye, Ming Fu

AU - Xiao, Lian Sheng

AU - Craig Hall, M.

PY - 1995

Y1 - 1995

N2 - Although interracial differences of prostate cancer progression are well recognized, their underlying molecular and cellular mechanisms remain obscure. We compared the histopathologic, immunohistochemical, and molecular characteristics of unselected prostate cancer tissues obtained from U.S., Chinese, and Japanese men. Histopathologic analyses indicated that 74.4% of the prostate cancers in Chinese men were poorly differentiated, compared with 28.6% and 32.8% of the prostate cancers in U.S. and Japanese men, respectively. These differences cannot be attributed to patient age, clinical stage of disease, or methods of tissue sampling. The high proportion of poorly differentiated prostate cancer tissues in the Chinese group was not related to the patients' access to medical service or to geographic background within China. Significantly higher levels of tumor angiogenesis (2- to 4-fold), serotonin (2- to 20-fold), and bombesin (7- to 16-fold), but not chromogranin A, were found in the tissue specimens obtained from Chinese prostate cancer patients compared with those from U.S. and Japanese patients. We also observed marked interracial differences in p53 protein accumulation. The protein was present in 90.2% of Chinese specimens; 17.4% of specimens from U.S. whites; 7.1% of specimens from Japanese men; and 3.7% of specimens from U.S. blacks. Results from multivariate logistic regression analysis demonstrated that p53 protein accumulation, angiogenesis, and serotonin expression in the normal stroma area correlate independently with Chinese versus non-Chinese patient populations.

AB - Although interracial differences of prostate cancer progression are well recognized, their underlying molecular and cellular mechanisms remain obscure. We compared the histopathologic, immunohistochemical, and molecular characteristics of unselected prostate cancer tissues obtained from U.S., Chinese, and Japanese men. Histopathologic analyses indicated that 74.4% of the prostate cancers in Chinese men were poorly differentiated, compared with 28.6% and 32.8% of the prostate cancers in U.S. and Japanese men, respectively. These differences cannot be attributed to patient age, clinical stage of disease, or methods of tissue sampling. The high proportion of poorly differentiated prostate cancer tissues in the Chinese group was not related to the patients' access to medical service or to geographic background within China. Significantly higher levels of tumor angiogenesis (2- to 4-fold), serotonin (2- to 20-fold), and bombesin (7- to 16-fold), but not chromogranin A, were found in the tissue specimens obtained from Chinese prostate cancer patients compared with those from U.S. and Japanese patients. We also observed marked interracial differences in p53 protein accumulation. The protein was present in 90.2% of Chinese specimens; 17.4% of specimens from U.S. whites; 7.1% of specimens from Japanese men; and 3.7% of specimens from U.S. blacks. Results from multivariate logistic regression analysis demonstrated that p53 protein accumulation, angiogenesis, and serotonin expression in the normal stroma area correlate independently with Chinese versus non-Chinese patient populations.

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