Comparing hippocampal atrophy in alzheimer's dementia and dementia with lewy bodies

Nicole Chow, Dag Aarsland, Hedieh Honarpisheh, Mona K. Beyer, Johanne H. Somme, David Elashoff, Arvid Rongve, Ole B. Tysnes, Paul M. Thompson, Liana G. Apostolova

Research output: Contribution to journalArticle

29 Scopus citations


Background/Aims: Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are the two most common neurodegenerative dementias. During the early stages, clinical distinction between them is often challenging. Our objective is to compare hippocampal atrophy patterns in mild AD and mild DLB. We hypothesized that DLB subjects have milder hippocampal atrophy relative to AD subjects. Methods: We analyzed the T1-weighted magnetic resonance imaging data from 113 subjects: 55 AD, 16 DLB and 42 cognitively normal elderly (normal controls, NC). Using the hippocampal radial distance technique and multiple linear regression, we analyzed the effect of clinical diagnosis on hippocampal radial distance, while adjusting for gender and age. Three-dimensional statistical maps were adjusted for multiple comparisons using permutation-based statistics with a threshold of p < 0.01. Results: Compared to NC, AD exhibited significantly greater atrophy in the cornu ammonis (CA)1, CA2-3 and subicular regions bilaterally while DLB showed left-predominant atrophy in the CA1 region and subiculum. Compared directly, AD and DLB did not reveal statistically significant differences. Conclusion: Hippocampal atrophy, while present in mildly impaired DLB subjects, is less severe than atrophy seen in mildly impaired AD subjects, when compared to NC. Both groups show predominant atrophy of the CA1 subfield and subiculum.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Issue number1
StatePublished - Sep 2012


  • Alzheimer's disease
  • Atrophy
  • Dementia with Lewy bodies
  • Hippocampus
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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    Chow, N., Aarsland, D., Honarpisheh, H., Beyer, M. K., Somme, J. H., Elashoff, D., Rongve, A., Tysnes, O. B., Thompson, P. M., & Apostolova, L. G. (2012). Comparing hippocampal atrophy in alzheimer's dementia and dementia with lewy bodies. Dementia and Geriatric Cognitive Disorders, 34(1), 44-50.