Comparison of acid secretory responsiveness to gastrin heptadecapeptide and of gastrin heptadecapeptide pharmacokinetics in duodenal ulcer patients and normal subjects

A. J. Blair, C. T. Richardson, Michael Vasko, J. H. Walsh, M. Feldman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Serum gastrin concentrations and gastric acid secretion were measured during intravenous infusion of gastrin heptadecapeptide (G-17) (0, 7, 22.1, 70, 221, and 700 pmol/kg · h) in 15 duodenal ulcer patients and 15 healthy controls. Ulcer patients developed higher serum gastrin concentrations during G-17 infusion due to nearly twofold slower clearance of gastrin (8.8 vs. 15.7 ml/kg · min; P <0.01). Despite slower clearance of G-17, ulcer patients had plasma elimination half-times for G-17 similar to controls (6.0 vs. 6.1 min, respectively). Thus, calculated volume of distribution for G-17 was lower in ulcer patients than controls (78.5 vs. 140.7 ml/kg; P <0.025). For any serum gastrin during gastrin-17 infusion, acid secretion (millimoles per hour) was higher in ulcer patients than in controls. However, when acid secretion was expressed as a percentage of peak acid output to G-17 (to correct for differences in parietal cell mass), curves relating acid secretion to serum gastrin were identical in ulcer patients and controls.

Original languageEnglish (US)
Pages (from-to)779-783
Number of pages5
JournalJournal of Clinical Investigation
Volume78
Issue number3
StatePublished - 1986
Externally publishedYes

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Duodenal Ulcer
Pharmacokinetics
Gastrins
Acids
Ulcer
Serum
gastrin 17
Gastric Acid
Intravenous Infusions

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Comparison of acid secretory responsiveness to gastrin heptadecapeptide and of gastrin heptadecapeptide pharmacokinetics in duodenal ulcer patients and normal subjects. / Blair, A. J.; Richardson, C. T.; Vasko, Michael; Walsh, J. H.; Feldman, M.

In: Journal of Clinical Investigation, Vol. 78, No. 3, 1986, p. 779-783.

Research output: Contribution to journalArticle

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AU - Walsh, J. H.

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