Abstract
Using data from The Collaborative Study on the Genetics of Alcoholism, we compare direct interview diagnoses of alcohol dependence to those obtained by history from family members. Using a requirement of three or more positive implications by history, the specificity, sensitivity, and positive predictive values are 98%, 39%, and 45%, respectively. A logistic analysis found the gender of the relative and alcoholism in the informant to be significant, but not the gender of the informant. The partial odds ratio of a diagnosis at interview associated with a positive family history diagnosis was 13.6. The relationship between the informant and relative was significant, with negative reports from an offspring or mate more influential than a negative report from a parent or second-degree relative. We derived a recursive equation to combine a variable number of family history reports, wherein the probabilities associated with a single report are computed from the logistic analysis. This permits the use of family history information both as a proxy for an uninterviewed relative, as well as a second source of information to be used in the analysis of genetic family data.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1018-1023 |
| Number of pages | 6 |
| Journal | Alcoholism: Clinical and Experimental Research |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1995 |
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Keywords
- DSM-III-R Alcohol Dependence
- Family History Diagnoses
- Genetic Analysis
- Specificity
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology
Cite this
Comparison of direct interview and family history diagnoses of alcohol dependence. / Rice, J. P.; Reich, T.; Bucholz, K. K.; Neuman, R. J.; Fishman, R.; Rochberg, N.; Hesselbrock, V. M.; Nurnberger, John; Schuckit, M. A.; Begleiter, H.
In: Alcoholism: Clinical and Experimental Research, Vol. 19, No. 4, 1995, p. 1018-1023.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of direct interview and family history diagnoses of alcohol dependence
AU - Rice, J. P.
AU - Reich, T.
AU - Bucholz, K. K.
AU - Neuman, R. J.
AU - Fishman, R.
AU - Rochberg, N.
AU - Hesselbrock, V. M.
AU - Nurnberger, John
AU - Schuckit, M. A.
AU - Begleiter, H.
PY - 1995
Y1 - 1995
N2 - Using data from The Collaborative Study on the Genetics of Alcoholism, we compare direct interview diagnoses of alcohol dependence to those obtained by history from family members. Using a requirement of three or more positive implications by history, the specificity, sensitivity, and positive predictive values are 98%, 39%, and 45%, respectively. A logistic analysis found the gender of the relative and alcoholism in the informant to be significant, but not the gender of the informant. The partial odds ratio of a diagnosis at interview associated with a positive family history diagnosis was 13.6. The relationship between the informant and relative was significant, with negative reports from an offspring or mate more influential than a negative report from a parent or second-degree relative. We derived a recursive equation to combine a variable number of family history reports, wherein the probabilities associated with a single report are computed from the logistic analysis. This permits the use of family history information both as a proxy for an uninterviewed relative, as well as a second source of information to be used in the analysis of genetic family data.
AB - Using data from The Collaborative Study on the Genetics of Alcoholism, we compare direct interview diagnoses of alcohol dependence to those obtained by history from family members. Using a requirement of three or more positive implications by history, the specificity, sensitivity, and positive predictive values are 98%, 39%, and 45%, respectively. A logistic analysis found the gender of the relative and alcoholism in the informant to be significant, but not the gender of the informant. The partial odds ratio of a diagnosis at interview associated with a positive family history diagnosis was 13.6. The relationship between the informant and relative was significant, with negative reports from an offspring or mate more influential than a negative report from a parent or second-degree relative. We derived a recursive equation to combine a variable number of family history reports, wherein the probabilities associated with a single report are computed from the logistic analysis. This permits the use of family history information both as a proxy for an uninterviewed relative, as well as a second source of information to be used in the analysis of genetic family data.
KW - DSM-III-R Alcohol Dependence
KW - Family History Diagnoses
KW - Genetic Analysis
KW - Specificity
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U2 - 10.1111/j.1530-0277.1995.tb00983.x
DO - 10.1111/j.1530-0277.1995.tb00983.x
M3 - Article
VL - 19
SP - 1018
EP - 1023
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
SN - 0145-6008
IS - 4
ER -