Abstract
Using data from The Collaborative Study on the Genetics of Alcoholism, we compare direct interview diagnoses of alcohol dependence to those obtained by history from family members. Using a requirement of three or more positive implications by history, the specificity, sensitivity, and positive predictive values are 98%, 39%, and 45%, respectively. A logistic analysis found the gender of the relative and alcoholism in the informant to be significant, but not the gender of the informant. The partial odds ratio of a diagnosis at interview associated with a positive family history diagnosis was 13.6. The relationship between the informant and relative was significant, with negative reports from an offspring or mate more influential than a negative report from a parent or second‐degree relative. We derived a recursive equation to combine a variable number of family history reports, wherein the probabilities associated with a single report are computed from the logistic analysis. This permits the use of family history information both as a proxy for an uninterviewed relative, as well as a second source of information to be used in the analysis of genetic family data.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1018-1023 |
| Number of pages | 6 |
| Journal | Alcoholism: Clinical and Experimental Research |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1995 |
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Keywords
- DSM‐III‐R Alcohol Dependence
- Family History Diagnoses
- Genetic Analysis
- Specificity
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology
- Psychiatry and Mental health
Cite this
Comparison of Direct Interview and Family History Diagnoses of Alcohol Dependence. / Rice, John P.; Reich, Theodore; Bucholz, Kathleen K.; Neuman, Rosalind J.; Fishman, Roberta; Rochberg, Nanette; Hesselbrock, Victor M.; Nurnberger, John I.; Schuckit, Marc A.; Begleiter, Henri.
In: Alcoholism: Clinical and Experimental Research, Vol. 19, No. 4, 08.1995, p. 1018-1023.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of Direct Interview and Family History Diagnoses of Alcohol Dependence
AU - Rice, John P.
AU - Reich, Theodore
AU - Bucholz, Kathleen K.
AU - Neuman, Rosalind J.
AU - Fishman, Roberta
AU - Rochberg, Nanette
AU - Hesselbrock, Victor M.
AU - Nurnberger, John I.
AU - Schuckit, Marc A.
AU - Begleiter, Henri
PY - 1995/8
Y1 - 1995/8
N2 - Using data from The Collaborative Study on the Genetics of Alcoholism, we compare direct interview diagnoses of alcohol dependence to those obtained by history from family members. Using a requirement of three or more positive implications by history, the specificity, sensitivity, and positive predictive values are 98%, 39%, and 45%, respectively. A logistic analysis found the gender of the relative and alcoholism in the informant to be significant, but not the gender of the informant. The partial odds ratio of a diagnosis at interview associated with a positive family history diagnosis was 13.6. The relationship between the informant and relative was significant, with negative reports from an offspring or mate more influential than a negative report from a parent or second‐degree relative. We derived a recursive equation to combine a variable number of family history reports, wherein the probabilities associated with a single report are computed from the logistic analysis. This permits the use of family history information both as a proxy for an uninterviewed relative, as well as a second source of information to be used in the analysis of genetic family data.
AB - Using data from The Collaborative Study on the Genetics of Alcoholism, we compare direct interview diagnoses of alcohol dependence to those obtained by history from family members. Using a requirement of three or more positive implications by history, the specificity, sensitivity, and positive predictive values are 98%, 39%, and 45%, respectively. A logistic analysis found the gender of the relative and alcoholism in the informant to be significant, but not the gender of the informant. The partial odds ratio of a diagnosis at interview associated with a positive family history diagnosis was 13.6. The relationship between the informant and relative was significant, with negative reports from an offspring or mate more influential than a negative report from a parent or second‐degree relative. We derived a recursive equation to combine a variable number of family history reports, wherein the probabilities associated with a single report are computed from the logistic analysis. This permits the use of family history information both as a proxy for an uninterviewed relative, as well as a second source of information to be used in the analysis of genetic family data.
KW - DSM‐III‐R Alcohol Dependence
KW - Family History Diagnoses
KW - Genetic Analysis
KW - Specificity
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UR - http://www.scopus.com/inward/citedby.url?scp=0029143219&partnerID=8YFLogxK
U2 - 10.1111/j.1530-0277.1995.tb00983.x
DO - 10.1111/j.1530-0277.1995.tb00983.x
M3 - Article
C2 - 7485811
AN - SCOPUS:0029143219
VL - 19
SP - 1018
EP - 1023
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
SN - 0145-6008
IS - 4
ER -