Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects

B. Kuo, R. W. McCallum, K. L. Koch, M. D. Sitrin, John Wo, W. D. Chey, W. L. Hasler, J. M. Lackner, L. A. Katz, J. R. Semler, G. E. Wilding, H. P. Parkman

Research output: Contribution to journalArticle

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Abstract

Background: Gastric emptying scintigraphy (GES) using a radio-labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET). Aims: To compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discriminating healthy subjects from gastroparetics. Methods: Eighty-seven healthy subjects and 61 gastroparetics enrolled with simultaneous SmartPill and GES. Fasted subjects were ingested capsule and [99mTc]-SC radio-labelled meal. Images were obtained every 30 min for 6 h. Gastric emptying time and percentage of meal remaining at 2/4 h were determined for each subject. The sensitivity/specificity and receiver operating characteristic analysis of each measure were determined for each subject. Results: Correlation between GET and GES-4 h was 0.73 and GES-2 h was 0.63. The diagnostic accuracy from the receiver operating characteristic curve between gastroparetics and healthy subjects was GET = 0.83, GES-4 h = 0.82 and GES-2 h = 0.79. The 300-min cut-off time for GET gives sensitivity of 0.65 and specificity of 0.87 for diagnosis of gastroparesis. The corresponding sensitivity/specificity for 2 and 4 h standard GES measures were 0.34/0.93 and 0.44/0.93, respectively. Conclusion: SmartPill GET correlates with GES and discriminates between healthy and gastroparetic subjects offering a nonradioactive, standardized, ambulatory alternative to scintigraphy.

Original languageEnglish (US)
Pages (from-to)186-196
Number of pages11
JournalAlimentary Pharmacology and Therapeutics
Volume27
Issue number2
DOIs
StatePublished - Jan 2008
Externally publishedYes

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Gastric Emptying
Radio
Capsules
Meals
Healthy Volunteers
Radionuclide Imaging
Sensitivity and Specificity
ROC Curve
Gastrointestinal Transit
Gastroparesis

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects. / Kuo, B.; McCallum, R. W.; Koch, K. L.; Sitrin, M. D.; Wo, John; Chey, W. D.; Hasler, W. L.; Lackner, J. M.; Katz, L. A.; Semler, J. R.; Wilding, G. E.; Parkman, H. P.

In: Alimentary Pharmacology and Therapeutics, Vol. 27, No. 2, 01.2008, p. 186-196.

Research output: Contribution to journalArticle

Kuo, B, McCallum, RW, Koch, KL, Sitrin, MD, Wo, J, Chey, WD, Hasler, WL, Lackner, JM, Katz, LA, Semler, JR, Wilding, GE & Parkman, HP 2008, 'Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects', Alimentary Pharmacology and Therapeutics, vol. 27, no. 2, pp. 186-196. https://doi.org/10.1111/j.1365-2036.2007.03564.x
Kuo, B. ; McCallum, R. W. ; Koch, K. L. ; Sitrin, M. D. ; Wo, John ; Chey, W. D. ; Hasler, W. L. ; Lackner, J. M. ; Katz, L. A. ; Semler, J. R. ; Wilding, G. E. ; Parkman, H. P. / Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects. In: Alimentary Pharmacology and Therapeutics. 2008 ; Vol. 27, No. 2. pp. 186-196.
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T1 - Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects

AU - Kuo, B.

AU - McCallum, R. W.

AU - Koch, K. L.

AU - Sitrin, M. D.

AU - Wo, John

AU - Chey, W. D.

AU - Hasler, W. L.

AU - Lackner, J. M.

AU - Katz, L. A.

AU - Semler, J. R.

AU - Wilding, G. E.

AU - Parkman, H. P.

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N2 - Background: Gastric emptying scintigraphy (GES) using a radio-labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET). Aims: To compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discriminating healthy subjects from gastroparetics. Methods: Eighty-seven healthy subjects and 61 gastroparetics enrolled with simultaneous SmartPill and GES. Fasted subjects were ingested capsule and [99mTc]-SC radio-labelled meal. Images were obtained every 30 min for 6 h. Gastric emptying time and percentage of meal remaining at 2/4 h were determined for each subject. The sensitivity/specificity and receiver operating characteristic analysis of each measure were determined for each subject. Results: Correlation between GET and GES-4 h was 0.73 and GES-2 h was 0.63. The diagnostic accuracy from the receiver operating characteristic curve between gastroparetics and healthy subjects was GET = 0.83, GES-4 h = 0.82 and GES-2 h = 0.79. The 300-min cut-off time for GET gives sensitivity of 0.65 and specificity of 0.87 for diagnosis of gastroparesis. The corresponding sensitivity/specificity for 2 and 4 h standard GES measures were 0.34/0.93 and 0.44/0.93, respectively. Conclusion: SmartPill GET correlates with GES and discriminates between healthy and gastroparetic subjects offering a nonradioactive, standardized, ambulatory alternative to scintigraphy.

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