Comparison of joint degeneration models

Surgical instability and repetitive impulsive loading

Martin Lukoschek, Robert D. Boyd, Mitchell B. Schaffler, David Burr, Eric L. Radin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We used surgical instability and repetitive impulsive loading in rabbits to initiate degenerative changes in knee joints. Synovial membrane and cartilage samples were examined by light and electron microscopy. Early synovial inflammation at three days postoperatively preceeded cartilage destruction in the instability model. Synovial inflammation was only apparent after eight weeks in the loading model and increased subsequently to cartilage destruction. Cartilage breakdown was focal and limited to the weight-bearing area. Comparison of the histological data of the two arthrosis models suggests that different inductive mechanisms may be involved in cartilage degeneration, but in both models the inflammatory changes appeared to be secondary to mechanical factors.

Original languageEnglish (US)
Pages (from-to)349-353
Number of pages5
JournalActa Orthopaedica
Volume57
Issue number4
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Anatomic Models
Cartilage
Joints
Inflammation
Synovial Membrane
Joint Diseases
Weight-Bearing
Knee Joint
Electron Microscopy
Rabbits
Light

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

Comparison of joint degeneration models : Surgical instability and repetitive impulsive loading. / Lukoschek, Martin; Boyd, Robert D.; Schaffler, Mitchell B.; Burr, David; Radin, Eric L.

In: Acta Orthopaedica, Vol. 57, No. 4, 1986, p. 349-353.

Research output: Contribution to journalArticle

Lukoschek, Martin ; Boyd, Robert D. ; Schaffler, Mitchell B. ; Burr, David ; Radin, Eric L. / Comparison of joint degeneration models : Surgical instability and repetitive impulsive loading. In: Acta Orthopaedica. 1986 ; Vol. 57, No. 4. pp. 349-353.
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