Comparison of ketamine-induced thought disorder in healthy volunteers and thought disorder in schizophrenia

Caleb M. Adler, Anil K. Malhotra, Igor Elman, Terry Goldberg, Michael Egan, David Pickar, Alan Breier

Research output: Contribution to journalArticle

260 Scopus citations

Abstract

Objective: This study sought to determine whether thought disorder induced in healthy volunteers by the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine resembles the thought disorder found in patients with schizophrenia. Method: The Scale for the Assessment of Thought, Language, and Communication was used to assess thought disorder in healthy volunteers (N=10) who received subanesthetic doses of ketamine and in a group of clinically stable inpatients with schizophrenia (N=15) who did not receive ketamine. Results: Mean scores on the Scale for the Assessment of Thought, Language, and Communication for patients with schizophrenia and healthy volunteers receiving ketamine did not differ significantly. Moreover, three of the four highest rated test items in both groups were the same. Conclusions: These data suggest that ketamine-induced thought disorder in healthy volunteers is not dissimilar to the thought disorder in patients with schizophrenia and provide support for the involvement of the NMDA receptor in a cardinal symptom of schizophrenia.

Original languageEnglish (US)
Pages (from-to)1646-1649
Number of pages4
JournalAmerican Journal of Psychiatry
Volume156
Issue number10
DOIs
StatePublished - Oct 1999
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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