Comparison of Mesial Versus Neocortical Onset Temporal Lobe Seizures: Neurodiagnostic Findings and Surgical Outcome

Robert S. Burgerman, Michael R. Sperling, Jacqueline A. French, Andrew J. Saykin, Michael J. O'Connor

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Summary: We compared historical features, surface EEG findings, results of intracarotid sodium amobarbital memory testing (IAT), and outcome after anterotemporal lobectomy (ATL) in patients with mesiotemporal lobe seizure onset with those with more diffuse temporal lobe seizure onset (intracranial EEG). Forty‐eight patients evaluated consecutively between July 1985 and October 1991 with both scalp/sphenoidal and intracranial EEG were shown to have seizures originating in one temporal lobe. No patients had temporal lobe tumor or vascular malformation. Thirty‐seven of the 48 patients had seizure onset in the amygdale/hippocampus (amyg/hipp). Eleven of the 48 had either temporal neocortical onset or simultaneous amydhipp and neocortical onset. Patients with mesial onset seizures were more likely to have lateralized memory impairment on I AT (p = 0.05). We noted a trend toward a difference in age of first risk for epilepsy between the two groups (p = 0.09) but not for a difference in any specific risk factor. There were no significant differences in surface EEG interictal findings. Unlike in previous studies, comparison of outcome between the two groups showed no difference in seizure‐free outcome. Sudden unexpected death (SUD) was more frequent in neocortical seizure patients who were not seizure‐free (p < 0.05).

Original languageEnglish (US)
Pages (from-to)662-670
Number of pages9
JournalEpilepsia
Volume36
Issue number7
DOIs
StatePublished - Jul 1995
Externally publishedYes

Keywords

  • Epilepsy
  • Mesial
  • Neocortical
  • Neurosurgery
  • Prognosis
  • Sudden death
  • Temporal lobe

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Comparison of Mesial Versus Neocortical Onset Temporal Lobe Seizures: Neurodiagnostic Findings and Surgical Outcome'. Together they form a unique fingerprint.

  • Cite this