Comparison of mononuclear cell proteins and plasma proteins before and during parturition by two dimensional electrophoresis

Giuseppe Del Priore, Robert Chatterton, Chung Lee, Richard Silver, Lori Berg, Men Jean Lee

Research output: Contribution to journalArticle

4 Scopus citations


Two dimensional electrophoresis is a technique whereby protein sources are organized by molecular weight and electrical charge on a Polyacrylamide gel. To detect changes that may be associated with the onset of parturition, we compared electrophoresis patterns of mononuclear cell proteins and plasma proteins before and during active labor. Mononuclear cells and plasma were obtained from 5 pregnant volunteers. It appears that A-1 apolipoprotein, identified by Western Blot analysis, is increased in mononuclear cells during active labor. Conversely, a decrease in the concentration of A-1 apolipoprotein was seen in plasma during parturition. These “normal” protein patterns can now be compared with those observed in pathologic conditions including preterm labor and may allow early detection of disease by protein abnormalities before clinical signs and symptoms develop.

Original languageEnglish (US)
Pages (from-to)373-377
Number of pages5
JournalJournal of Perinatal Medicine
Issue number5
StatePublished - Jan 1991



  • Geburt
  • Leukocytes
  • Leukozyten
  • Plasma
  • parturition
  • plasma
  • two dimensional Polyacrylamide gel electrophoresis
  • zweidimensionale Polyacrylamid-Gelelektrophorese

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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