Comparison of once daily levobunolol 0.5% versus timolol XE 0.5% for the control of intraocular pressure and patient comfort

L. B. Cantor, N. P. Alvi, J. S. Hoop, L. J. Katz, K. Flartey, E. J. Brizendine, V. D. Bhavnani

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Purpose: To compare intraocular pressure and patient comfort with Levobunolol 0.5% versus Timolol XE 0.5% both used once daily in patients with open angle glaucoma or ocular hypertension. Method: 40 subjects were prospectively randomized in a two period, two treatment crossover study at two centers. Subjects were randomized to one of two drug sequences for six weeks and then crossed over to the opposite drug for the following six weeks. Intraocular pressures (IOP) and slit lamp examinations were performed at baseline, weeks 1, 6, 7, and 12. Questionnaires regarding ocular symptoms were obtained immediately after medication was given and at week 12 on all patients. An analysis of variance model was used to analyze one randomly selected eye from each subject. Results: 36 patients completed the study. There were no significant differences in race, sex, center, mean age or IOP at baseline (p< 0.05 was deemed significant) between drug sequence assignment. Baseline Levobunolol Timolol p-value (n=36) (n=35) (n=35) IOP mean±SD 26.0 ± 4.3 20.7 ± 501 20.8 ± 3.9 0.96 % Decrease IOP 20.1 ±16.1 19.0 ± 12.5 0.74 There was no difference in patient comfort or preference between the two groups. Conclusions: Levobunolol 0.5% is as effective and similar in patient comfort as Timolol XE 0.5%.

Original languageEnglish (US)
Pages (from-to)S558
JournalInvestigative Ophthalmology and Visual Science
Issue number4
StatePublished - Dec 1 1997


ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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