Comparison of outcomes in patients with intracranial hemorrhage on factor Xa inhibitors versus vitamin K antagonists treated with 4-factor prothrombin complex concentrate

Sarah K. Harrison, John S. Garrett, Kelsey N. Kohman, Jeffrey Kline

Research output: Contribution to journalArticle

6 Scopus citations


The relative clinical efficacy of 4-factor prothrombin complex concentrate (4F-PCC) in oral anticoagulant–associated intracranial hemorrhage is unknown, especially for factor Xa–inhibiting anticoagulants. We report short-term outcomes of patients with oral anticoagulant–associated intracranial hemorrhage on vitamin K antagonists and factor Xa inhibitors who were treated with 4F-PCC. This multicenter, observational study involved patients presenting to the emergency department in nine hospitals in an integrated health care delivery system in Texas between July 2013 and December 2015. Forty-two patients diagnosed with oral anticoagulant–associated intracranial hemorrhage—24 taking a vitamin K antagonist and 14 taking a factor Xa inhibitor—were treated with 4F-PCC as part of usual care. Study patients had similar baseline demographics, with the exception of suspected etiology of hemorrhage. Outcomes of the vitamin K antagonist group were similar to those of the factor Xa inhibitor group, with no significant differences in overall in-hospital mortality (32.1% vs 14.2%, respectively), length of stay, or rates of hemorrhagic expansion, thromboembolism, or discharge to home. In conclusion, this small sample of patients with oral factor Xa inhibitor and vitamin K antagonist–associated intracranial hemorrhage treated with 4F-PCC had similar mortality and neurological outcomes, with no venous thromboembolic events.

Original languageEnglish (US)
Pages (from-to)153-156
Number of pages4
JournalBaylor University Medical Center Proceedings
Issue number2
StatePublished - Apr 3 2018



  • 4-factor prothrombin complex concentrate
  • emergent reversal
  • fresh frozen plasma
  • intracranial hemorrhage
  • oral anticoagulation

ASJC Scopus subject areas

  • Medicine(all)

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