Comparison of pain and postoperative stress in dogs undergoing natural orifice transluminal endoscopic surgery, laparoscopic, and open oophorectomy

Lynetta J. Freeman, Emad Y. Rahmani, Mohammad Al-Haddad, Stuart Sherman, Michael V. Chiorean, Don Selzer, Paul W. Snyder, Peter D. Constable

Research output: Contribution to journalArticle

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Abstract

Background: Few studies are available to compare the potential benefits of natural orifice transluminal endoscopic surgery (NOTES) approaches to traditional surgery. Objective: To compare complications, surgical stress, and postoperative pain. Design: Prospective study in dogs. Setting: Research laboratory. Subjects: Thirty dogs. Interventions: Oophorectomy procedures were performed via NOTES and laparoscopic and traditional open surgery. Main Outcome Measurements: Operative time, pain scores, systemic stress parameters (cortisol, glucose), surgical stress markers (interleukin 6, C-reactive protein), 3-day observation. Results: Median operative times were 76, 44, and 35 minutes for the NOTES, laparoscopic, and open procedures, respectively, with the NOTES procedure being significantly longer than the other 2 procedures. All ovaries were completely excised, and all the animals survived without complications. The NOTES animals had greater increases in serum cortisol concentrations at 2 hours but no statistically significant differences in glucose concentrations compared with the other groups. Serum interleukin 6 and C-reactive protein concentrations were significantly increased at specific times compared with baseline in the NOTES group, but not in the open or laparoscopic surgery groups. Based on the cumulative pain score and nociceptive thresholds, the animals in the NOTES group demonstrated less evidence of pain. Limitations: Small sample size, limited follow-up. Conclusions: Although the NOTES oophorectomy procedures took approximately twice as long and there may be more evidence of tissue damage as judged by increases in serum cortisol and interleukin 6 concentrations, the dogs in the NOTES group had lower pain scores, especially when compared with animals undergoing open surgery.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalGastrointestinal Endoscopy
Volume72
Issue number2
DOIs
StatePublished - Aug 2010

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Natural Orifice Endoscopic Surgery
Ovariectomy
Postoperative Pain
Dogs
Hydrocortisone
Interleukin-6
Operative Time
Pain
C-Reactive Protein
Serum
Nociceptive Pain
Glucose
Sample Size
Laparoscopy
Ovary
Observation
Prospective Studies

ASJC Scopus subject areas

  • Gastroenterology
  • Radiology Nuclear Medicine and imaging

Cite this

Comparison of pain and postoperative stress in dogs undergoing natural orifice transluminal endoscopic surgery, laparoscopic, and open oophorectomy. / Freeman, Lynetta J.; Rahmani, Emad Y.; Al-Haddad, Mohammad; Sherman, Stuart; Chiorean, Michael V.; Selzer, Don; Snyder, Paul W.; Constable, Peter D.

In: Gastrointestinal Endoscopy, Vol. 72, No. 2, 08.2010, p. 373-380.

Research output: Contribution to journalArticle

Freeman, Lynetta J. ; Rahmani, Emad Y. ; Al-Haddad, Mohammad ; Sherman, Stuart ; Chiorean, Michael V. ; Selzer, Don ; Snyder, Paul W. ; Constable, Peter D. / Comparison of pain and postoperative stress in dogs undergoing natural orifice transluminal endoscopic surgery, laparoscopic, and open oophorectomy. In: Gastrointestinal Endoscopy. 2010 ; Vol. 72, No. 2. pp. 373-380.
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