Comparison of polyethylene glycol-electrolyte solution vs polyethylene glycol-3350 for the treatment of fecal impaction in pediatric patients

Erin E. Boles, Cameryn L. Gaines, Emma M. Tillman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

OBJECTIVES: The objective of this study was to evaluate the safety and efficacy of polyethylene glycolelectrolyte solution vs polyethylene glycol-3350 for the treatment of fecal impaction in pediatric patients. METHODS: A retrospective, observational, institutional review board–approved study was conducted over a 1-year time period. Patients were included in the study if they were admitted to the hospital with a diagnosis of fecal impaction or constipation and were treated with either polyethylene glycol-electrolyte solution (PEG-ES) or polyethylene glycol-3350 (PEG-3350). Patients were excluded if they were discharged prior to resolution of treatment and/or did not receive PEG-ES or PEG-3350. RESULTS: Fifty-one patients (ranging in age from 1 month to 15 years) were evaluated: 23 patients received PEG-ES and 28 patients received PEG-3350. Sex, race, age, and weight were not statistically different between the 2 groups. Resolution of fecal impaction was not significantly different between PEG-ES vs PEG-3350 (87% and 86%, respectively; p = 0.87). There was only 1 reported side effect with PEG-3350, vs 11 reported side effects with PEG-ES (p < 0.01). CONCLUSIONS: Theses results suggest that PEG-3350 is as effective as PEG-ES for the treatment of fecal impaction in pediatric patients and is associated with fewer side effects.

Original languageEnglish (US)
Pages (from-to)210-216
Number of pages7
JournalJournal of Pediatric Pharmacology and Therapeutics
Volume20
Issue number3
DOIs
StatePublished - May 1 2015

Keywords

  • Constipation
  • Fecal impaction
  • Pediatrics
  • Polyethylene glycol-3350
  • Polyethylene glycol-electrolyte solution

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Comparison of polyethylene glycol-electrolyte solution vs polyethylene glycol-3350 for the treatment of fecal impaction in pediatric patients'. Together they form a unique fingerprint.

Cite this