Comparison of pulsatile perfusion and cold storage for paired kidney allografts

Ashesh P. Shah, Daniel P. Milgrom, Richard S. Mangus, John A. Powelson, William C. Goggins, Milgrom L. Milgrom

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Use of pulsatile perfusion to optimize outcomes in deceased donor kidney transplantation remains controversial. This study is a retrospective analysis of all cadaveric renal allografts procured locally by our center over a 3-year period. Kidney pairs were identified in which one kidney underwent pulsatile perfusion and transplantation at our center, whereas the contra-lateral kidney underwent cold storage and transplantation at another center. Eighty-eight percent of the exported kidneys were six-antigen matches. Study outcomes included 1-year graft and patient survival, delayed graft function, and need for posttransplant dialysis. Recipients had similar demographic and disease characteristics. Survival for pulsatile perfusion and cold storage were 95% and 88% (graft, P=0.43) and 98% and 90% (patient, P=0.36), respectively. The incidence of delayed graft function was 5% and 35% (P<0.01), whereas posttransplant dialysis was 5% and 30% (P<0.01), for pulsatile perfusion and cold storage, respectively. These data support routine use of pulsatile perfusion.

Original languageEnglish (US)
Pages (from-to)1006-1009
Number of pages4
JournalTransplantation
Volume86
Issue number7
DOIs
StatePublished - Oct 15 2008

Keywords

  • Acute tubular necrosis
  • Delayed
  • Graft function
  • Pulsatile perfusion
  • Renal transplantation

ASJC Scopus subject areas

  • Transplantation

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