Comparison of radiofrequency ablation, cryoablation, and nephrectomy in treating implanted VX-2 carcinoma in rabbit kidneys

Stephen Y. Nakada, Travis Jerde, Thomas F. Warner, Fred T. Lee

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Abstract

Purpose: To compare the efficacy of radiofrequency (RF) ablation, cryoablation, and radical nephrectomy in the treatment of implanted VX-2 carcinoma in rabbit kidneys. Materials and Methods: Sixty-eight New Zealand White rabbits were implanted with 1-mm3 segments of VX-2 carcinoma in the left kidney. Seven days after implantation, the tumors were treated with one of the following: (1) RF ablation using a 12-gauge electrode (RITA Medical Systems, Mountain View, CA) at 90°C for 8 minutes with a 5-mm tumor margin target temperature of 60°C (N = 20); (2) cryoablation using a 15-minute double-freeze technique with 2.4-mm cryoprobes and the Cryocare system (Endocare Inc., Irvine, CA) with a 5-mm tumor margin target temperature of -20°C (N = 20); (3) open radical nephrectomy (N = 20); or (4) no treatment (controls; N = 8). Rabbits were allowed to survive for a total of 22 days and sacrificed; and the kidneys, lungs, liver, spleen, urinary bladder, and ureter were removed and examined grossly and histologically for tumor. Results: Findings in animals sacrificed at 15 days post-treatment showed significant differences between all treatment groups and untreated controls (P <0.002) Using a 3 × 2 chi-square comparison, no differences in disease-free survival were observed between the RF ablation group, the cryoablation group, and the open nephrectomy group (P = 0.72) Conclusion: Radiofrequency ablation, cryoablation, and radical nephrectomy were all efficacious in the treatment of implanted VX-2 renal tumors compared with untreated controls (P = 0.002). No statistically significant difference was found between any of the three treatments.

Original languageEnglish (US)
Pages (from-to)501-506
Number of pages6
JournalJournal of Endourology
Volume18
Issue number5
DOIs
StatePublished - Jun 2004
Externally publishedYes

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Cryosurgery
Nephrectomy
Rabbits
Carcinoma
Kidney
Neoplasms
Temperature
Ureter
Disease-Free Survival
Electrodes
Urinary Bladder
Spleen
VX
Lung
Control Groups
Liver

ASJC Scopus subject areas

  • Urology

Cite this

Comparison of radiofrequency ablation, cryoablation, and nephrectomy in treating implanted VX-2 carcinoma in rabbit kidneys. / Nakada, Stephen Y.; Jerde, Travis; Warner, Thomas F.; Lee, Fred T.

In: Journal of Endourology, Vol. 18, No. 5, 06.2004, p. 501-506.

Research output: Contribution to journalArticle

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AB - Purpose: To compare the efficacy of radiofrequency (RF) ablation, cryoablation, and radical nephrectomy in the treatment of implanted VX-2 carcinoma in rabbit kidneys. Materials and Methods: Sixty-eight New Zealand White rabbits were implanted with 1-mm3 segments of VX-2 carcinoma in the left kidney. Seven days after implantation, the tumors were treated with one of the following: (1) RF ablation using a 12-gauge electrode (RITA Medical Systems, Mountain View, CA) at 90°C for 8 minutes with a 5-mm tumor margin target temperature of 60°C (N = 20); (2) cryoablation using a 15-minute double-freeze technique with 2.4-mm cryoprobes and the Cryocare system (Endocare Inc., Irvine, CA) with a 5-mm tumor margin target temperature of -20°C (N = 20); (3) open radical nephrectomy (N = 20); or (4) no treatment (controls; N = 8). Rabbits were allowed to survive for a total of 22 days and sacrificed; and the kidneys, lungs, liver, spleen, urinary bladder, and ureter were removed and examined grossly and histologically for tumor. Results: Findings in animals sacrificed at 15 days post-treatment showed significant differences between all treatment groups and untreated controls (P <0.002) Using a 3 × 2 chi-square comparison, no differences in disease-free survival were observed between the RF ablation group, the cryoablation group, and the open nephrectomy group (P = 0.72) Conclusion: Radiofrequency ablation, cryoablation, and radical nephrectomy were all efficacious in the treatment of implanted VX-2 renal tumors compared with untreated controls (P = 0.002). No statistically significant difference was found between any of the three treatments.

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