Comparison of surgical procedures for vascular and airway anastomoses that utilize a "modified" non-suture external cuff technique for experimental lung transplantation in rats

Teruaki Mizobuchi, Yasuo Sekine, Kazuhiro Yasufuku, Takehiko Fujisawa, David S. Wilkes

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background Lung transplantation in rats is technically difficult and results may vary. The non-suture cuff technique (non-suture [NS]), which involves using a cuff for anastomoses of vessels and airways, is commonly utilized to perform transplant procedures. However, the standard bronchial cuff may occlude the lumen, resulting in diminished graft survival. In contrast, the non-suture cuff technique for vascular anastomoses with bronchial suturing (bronchial suture [BS]), although more technically difficult, is known to have prolonged bronchial patency. We developed a "modified" NS technique that uses a larger and longer cuff for anastomoses and compared the efficacy of this procedure to the BS technique for lung transplantation. Methods The BS procedure was performed in 146 transplant procedures. The modified NS procedure, which uses a larger cuff than the standard NS procedure, was performed in 113 procedures. Results Although total ischemic times were comparable, the total operation time in the NS group was significantly shorter than in the BS group (p < 0.0001). Bronchial leakage occurred in 9.6% of BS group patients and 0% of NS group patients. Survival rates were comparable between groups. Although the BS technique is widely acknowledged to provide prolonged patency of bronchial anastomosis, graft survival in the NS group was observed up 17 months post-transplant. Conclusions These data show that the NS technique, which is less technically difficult, results in shorter operative times compared with the BS procedure, and results in durable anastomoses of lung grafts.

Original languageEnglish (US)
Pages (from-to)889-893
Number of pages5
JournalJournal of Heart and Lung Transplantation
Volume23
Issue number7
DOIs
StatePublished - Jul 1 2004

Fingerprint

Vascular Surgical Procedures
Lung Transplantation
Sutures
Suture Techniques
Transplants
Graft Survival
Operative Time
Blood Vessels
Survival Rate

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Cite this

Comparison of surgical procedures for vascular and airway anastomoses that utilize a "modified" non-suture external cuff technique for experimental lung transplantation in rats. / Mizobuchi, Teruaki; Sekine, Yasuo; Yasufuku, Kazuhiro; Fujisawa, Takehiko; Wilkes, David S.

In: Journal of Heart and Lung Transplantation, Vol. 23, No. 7, 01.07.2004, p. 889-893.

Research output: Contribution to journalArticle

@article{609855a4d6ba45cab2755884a87b46d1,
title = "Comparison of surgical procedures for vascular and airway anastomoses that utilize a {"}modified{"} non-suture external cuff technique for experimental lung transplantation in rats",
abstract = "Background Lung transplantation in rats is technically difficult and results may vary. The non-suture cuff technique (non-suture [NS]), which involves using a cuff for anastomoses of vessels and airways, is commonly utilized to perform transplant procedures. However, the standard bronchial cuff may occlude the lumen, resulting in diminished graft survival. In contrast, the non-suture cuff technique for vascular anastomoses with bronchial suturing (bronchial suture [BS]), although more technically difficult, is known to have prolonged bronchial patency. We developed a {"}modified{"} NS technique that uses a larger and longer cuff for anastomoses and compared the efficacy of this procedure to the BS technique for lung transplantation. Methods The BS procedure was performed in 146 transplant procedures. The modified NS procedure, which uses a larger cuff than the standard NS procedure, was performed in 113 procedures. Results Although total ischemic times were comparable, the total operation time in the NS group was significantly shorter than in the BS group (p < 0.0001). Bronchial leakage occurred in 9.6{\%} of BS group patients and 0{\%} of NS group patients. Survival rates were comparable between groups. Although the BS technique is widely acknowledged to provide prolonged patency of bronchial anastomosis, graft survival in the NS group was observed up 17 months post-transplant. Conclusions These data show that the NS technique, which is less technically difficult, results in shorter operative times compared with the BS procedure, and results in durable anastomoses of lung grafts.",
author = "Teruaki Mizobuchi and Yasuo Sekine and Kazuhiro Yasufuku and Takehiko Fujisawa and Wilkes, {David S.}",
year = "2004",
month = "7",
day = "1",
doi = "10.1016/j.healun.2003.06.009",
language = "English (US)",
volume = "23",
pages = "889--893",
journal = "Journal of Heart and Lung Transplantation",
issn = "1053-2498",
publisher = "Elsevier USA",
number = "7",

}

TY - JOUR

T1 - Comparison of surgical procedures for vascular and airway anastomoses that utilize a "modified" non-suture external cuff technique for experimental lung transplantation in rats

AU - Mizobuchi, Teruaki

AU - Sekine, Yasuo

AU - Yasufuku, Kazuhiro

AU - Fujisawa, Takehiko

AU - Wilkes, David S.

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Background Lung transplantation in rats is technically difficult and results may vary. The non-suture cuff technique (non-suture [NS]), which involves using a cuff for anastomoses of vessels and airways, is commonly utilized to perform transplant procedures. However, the standard bronchial cuff may occlude the lumen, resulting in diminished graft survival. In contrast, the non-suture cuff technique for vascular anastomoses with bronchial suturing (bronchial suture [BS]), although more technically difficult, is known to have prolonged bronchial patency. We developed a "modified" NS technique that uses a larger and longer cuff for anastomoses and compared the efficacy of this procedure to the BS technique for lung transplantation. Methods The BS procedure was performed in 146 transplant procedures. The modified NS procedure, which uses a larger cuff than the standard NS procedure, was performed in 113 procedures. Results Although total ischemic times were comparable, the total operation time in the NS group was significantly shorter than in the BS group (p < 0.0001). Bronchial leakage occurred in 9.6% of BS group patients and 0% of NS group patients. Survival rates were comparable between groups. Although the BS technique is widely acknowledged to provide prolonged patency of bronchial anastomosis, graft survival in the NS group was observed up 17 months post-transplant. Conclusions These data show that the NS technique, which is less technically difficult, results in shorter operative times compared with the BS procedure, and results in durable anastomoses of lung grafts.

AB - Background Lung transplantation in rats is technically difficult and results may vary. The non-suture cuff technique (non-suture [NS]), which involves using a cuff for anastomoses of vessels and airways, is commonly utilized to perform transplant procedures. However, the standard bronchial cuff may occlude the lumen, resulting in diminished graft survival. In contrast, the non-suture cuff technique for vascular anastomoses with bronchial suturing (bronchial suture [BS]), although more technically difficult, is known to have prolonged bronchial patency. We developed a "modified" NS technique that uses a larger and longer cuff for anastomoses and compared the efficacy of this procedure to the BS technique for lung transplantation. Methods The BS procedure was performed in 146 transplant procedures. The modified NS procedure, which uses a larger cuff than the standard NS procedure, was performed in 113 procedures. Results Although total ischemic times were comparable, the total operation time in the NS group was significantly shorter than in the BS group (p < 0.0001). Bronchial leakage occurred in 9.6% of BS group patients and 0% of NS group patients. Survival rates were comparable between groups. Although the BS technique is widely acknowledged to provide prolonged patency of bronchial anastomosis, graft survival in the NS group was observed up 17 months post-transplant. Conclusions These data show that the NS technique, which is less technically difficult, results in shorter operative times compared with the BS procedure, and results in durable anastomoses of lung grafts.

UR - http://www.scopus.com/inward/record.url?scp=3242723857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242723857&partnerID=8YFLogxK

U2 - 10.1016/j.healun.2003.06.009

DO - 10.1016/j.healun.2003.06.009

M3 - Article

C2 - 15261185

AN - SCOPUS:3242723857

VL - 23

SP - 889

EP - 893

JO - Journal of Heart and Lung Transplantation

JF - Journal of Heart and Lung Transplantation

SN - 1053-2498

IS - 7

ER -