Comparison of survival rates after bland arterial embolization and ablation versus surgical resection for treating solitary hepatocellular carcinoma up to 7 cm

Mary Maluccio, Anne M. Covey, Ripal Gandhi, Mithat Gonen, George I. Getrajdman, Lynn A. Brody, Yuman Fong, William Jarnagin, Michael D'Angelica, Leslie Blumgart, Ronald Dematteo, Karen T. Brown

Research output: Contribution to journalArticle

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Abstract

PURPOSE: The vast majority of hepatocellular carcinomas (HCC) occur in patients with underlying liver dysfunction, making surgical resection available to only a subset of patients with adequate hepatic reserve. This study analyzes the authors' results with bland arterial embolization combined with radiofrequency ablation (RFA) or percutaneous ethanol injection (PEIT) compared with surgical resection for the treatment of solitary HCC up to 7 cm in size. MATERIALS AND METHODS: A retrospective review of all patients undergoing either surgical resection or bland embolization combined with local ablation for solitary HCC between January 1996 and August 2002 was performed. Progression-free survival rate and overall survival rate were calculated by the Kaplan-Meier method. RESULTS: There were 40 patients who underwent surgical resection and 33 patients who underwent embolization and ablation. Age, gender, and size of the treated lesion were not significantly different between the groups. The embolization/ablation group had more patients classified as Okuda stage II (P <.001). The surgical group had a longer median recurrence-free survival rate (53.1 vs 25.1 months). With a median follow-up of 23 months, the 1-, 3- and 5-year actuarial overall survival rates were 97%, 77%, and 56% for the embolization/ablation group and 81%, 70%, and 58% for the surgical group, respectively. There was no statistical difference in overall survival rates (P = .20). CONCLUSIONS: Bland arterial embolization in combination with ablation is effective in treating solitary HCC lesions up to 7 cm and achieves similar overall survival rates to surgical resection in selected patients.

Original languageEnglish (US)
Pages (from-to)955-961
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Volume16
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

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Hepatocellular Carcinoma
Survival Rate
Disease-Free Survival
Liver Diseases
Ethanol
Recurrence
Injections
Liver

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Comparison of survival rates after bland arterial embolization and ablation versus surgical resection for treating solitary hepatocellular carcinoma up to 7 cm. / Maluccio, Mary; Covey, Anne M.; Gandhi, Ripal; Gonen, Mithat; Getrajdman, George I.; Brody, Lynn A.; Fong, Yuman; Jarnagin, William; D'Angelica, Michael; Blumgart, Leslie; Dematteo, Ronald; Brown, Karen T.

In: Journal of Vascular and Interventional Radiology, Vol. 16, No. 7, 07.2005, p. 955-961.

Research output: Contribution to journalArticle

Maluccio, M, Covey, AM, Gandhi, R, Gonen, M, Getrajdman, GI, Brody, LA, Fong, Y, Jarnagin, W, D'Angelica, M, Blumgart, L, Dematteo, R & Brown, KT 2005, 'Comparison of survival rates after bland arterial embolization and ablation versus surgical resection for treating solitary hepatocellular carcinoma up to 7 cm', Journal of Vascular and Interventional Radiology, vol. 16, no. 7, pp. 955-961. https://doi.org/10.1097/01.RVI.0000161377.33557.20
Maluccio, Mary ; Covey, Anne M. ; Gandhi, Ripal ; Gonen, Mithat ; Getrajdman, George I. ; Brody, Lynn A. ; Fong, Yuman ; Jarnagin, William ; D'Angelica, Michael ; Blumgart, Leslie ; Dematteo, Ronald ; Brown, Karen T. / Comparison of survival rates after bland arterial embolization and ablation versus surgical resection for treating solitary hepatocellular carcinoma up to 7 cm. In: Journal of Vascular and Interventional Radiology. 2005 ; Vol. 16, No. 7. pp. 955-961.
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T1 - Comparison of survival rates after bland arterial embolization and ablation versus surgical resection for treating solitary hepatocellular carcinoma up to 7 cm

AU - Maluccio, Mary

AU - Covey, Anne M.

AU - Gandhi, Ripal

AU - Gonen, Mithat

AU - Getrajdman, George I.

AU - Brody, Lynn A.

AU - Fong, Yuman

AU - Jarnagin, William

AU - D'Angelica, Michael

AU - Blumgart, Leslie

AU - Dematteo, Ronald

AU - Brown, Karen T.

PY - 2005/7

Y1 - 2005/7

N2 - PURPOSE: The vast majority of hepatocellular carcinomas (HCC) occur in patients with underlying liver dysfunction, making surgical resection available to only a subset of patients with adequate hepatic reserve. This study analyzes the authors' results with bland arterial embolization combined with radiofrequency ablation (RFA) or percutaneous ethanol injection (PEIT) compared with surgical resection for the treatment of solitary HCC up to 7 cm in size. MATERIALS AND METHODS: A retrospective review of all patients undergoing either surgical resection or bland embolization combined with local ablation for solitary HCC between January 1996 and August 2002 was performed. Progression-free survival rate and overall survival rate were calculated by the Kaplan-Meier method. RESULTS: There were 40 patients who underwent surgical resection and 33 patients who underwent embolization and ablation. Age, gender, and size of the treated lesion were not significantly different between the groups. The embolization/ablation group had more patients classified as Okuda stage II (P <.001). The surgical group had a longer median recurrence-free survival rate (53.1 vs 25.1 months). With a median follow-up of 23 months, the 1-, 3- and 5-year actuarial overall survival rates were 97%, 77%, and 56% for the embolization/ablation group and 81%, 70%, and 58% for the surgical group, respectively. There was no statistical difference in overall survival rates (P = .20). CONCLUSIONS: Bland arterial embolization in combination with ablation is effective in treating solitary HCC lesions up to 7 cm and achieves similar overall survival rates to surgical resection in selected patients.

AB - PURPOSE: The vast majority of hepatocellular carcinomas (HCC) occur in patients with underlying liver dysfunction, making surgical resection available to only a subset of patients with adequate hepatic reserve. This study analyzes the authors' results with bland arterial embolization combined with radiofrequency ablation (RFA) or percutaneous ethanol injection (PEIT) compared with surgical resection for the treatment of solitary HCC up to 7 cm in size. MATERIALS AND METHODS: A retrospective review of all patients undergoing either surgical resection or bland embolization combined with local ablation for solitary HCC between January 1996 and August 2002 was performed. Progression-free survival rate and overall survival rate were calculated by the Kaplan-Meier method. RESULTS: There were 40 patients who underwent surgical resection and 33 patients who underwent embolization and ablation. Age, gender, and size of the treated lesion were not significantly different between the groups. The embolization/ablation group had more patients classified as Okuda stage II (P <.001). The surgical group had a longer median recurrence-free survival rate (53.1 vs 25.1 months). With a median follow-up of 23 months, the 1-, 3- and 5-year actuarial overall survival rates were 97%, 77%, and 56% for the embolization/ablation group and 81%, 70%, and 58% for the surgical group, respectively. There was no statistical difference in overall survival rates (P = .20). CONCLUSIONS: Bland arterial embolization in combination with ablation is effective in treating solitary HCC lesions up to 7 cm and achieves similar overall survival rates to surgical resection in selected patients.

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