Comparison of the four mouse fasciclin-containing genes expression patterns during valvuloseptal morphogenesis

Andrew Lindsley, Wei Li, Jian Wang, Nana Maeda, Rhonda Rogers, Simon J. Conway

Research output: Contribution to journalArticle

35 Scopus citations


All four mammalian fasciclin-containing genes are expressed in the adult valves and are localized in partially overlapping and reciprocal patterns during cardiovascular development. Spatiotemporal comparison of the fasciclin-containing secreted adhesion genes, TGFbeta induced clone H3 (βigH3) and periostin, revealed that they are co-localized within the outflow tract endocardial cushions, but that βigH3 expression is restricted to the septal cushions within the atrioventricular canal. Conversely, the fasciclin-containing transmembrane gene, stabilin-1, is predominately expressed in the endocardial layer overlaying the cushions and lining the developing heart. However, expression of the fasciclin-containing transmembrane gene, stabilin-2 is only present in the post-natal mature valve endothelial cells. These data illustrate for the first time that the primitive endocardial cushions dynamically express multiple fasciclin-containing adhesion molecules as they undergo the key steps of seeding, proliferation, differentiation, fusion, mesenchymal condensation and remodeling during mouse heart development.

Original languageEnglish (US)
Pages (from-to)593-600
Number of pages8
JournalGene Expression Patterns
Issue number5
StatePublished - Jun 2005


  • βigH3
  • Cardiac valve morphogenesis
  • Fasciclin domain
  • Mouse heart development
  • Periostin
  • Stabilin-1
  • Stabilin-2
  • TGFbeta induced clone H3

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

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